Τίτλος:
CSF and plasma cytokines at delivery and postpartum mood disturbances
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Immune activation has been shown to be involved in the pathophysiology of anxiety states and major depression and pregnancy is associated with a characteristic immune activation to sustain the fetus. Despite the possibility of a relation between immune parameters and postpartum mood disturbance, few studies have explored this association. Further, no study to-date has examined CSF. Methods: Fifty-six Greek parturients were recruited and a detailed medical and obstetric history was recorded. All of them completed the Postpartum Blues Questionnaire (on admission and on days 1-4 postpartum) and the Edinburgh Postnatal Depression Scale (at first and sixth week postpartum). At delivery, a blood sample and a CSF sample while puncturing for epidural analgesia were taken from 33 participants; blood samples only were obtained from the rest of the 23 parturients. TNF-a and IL-6 were quantified with an ELISA assay. Results: A multiple regression analysis of psychometric scores depending on cytokine levels revealed that cytokine levels were positively associated with depressive mood during the first four days postpartum (p = 0.035 for CSF IL-6, p = 0.025 for CSF TnF-a, p = 0.023 for serum TnF-a) and also at sixth week postpartum (p = 0.012 for CSF IL-6, p = 0.072 for CSF TnF-a). Pregnancy duration had an adverse association to psychometric scores. Conclusions: It is suggested that immune mechanisms may play a role in the etiopathology of postpartum depressive mood shifts. The role of a "rebound" reaction of the maternal immune system postnatal should be further investigated. © 2008 Elsevier B.V. All rights reserved.
Συγγραφείς:
Boufidou, F.
Lambrinoudaki, I.
Argeitis, J.
Zervas, I.M.
Pliatsika, P.
Leonardou, A.A.
Petropoulos, G.
Hasiakos, D.
Papadias, K.
Nikolaou, C.
Περιοδικό:
Journal of Affective Disorders
Λέξεις-κλειδιά:
interleukin 6; tumor necrosis factor alpha, adult; article; blood sampling; cerebrospinal fluid; delivery; enzyme linked immunosorbent assay; epidural anesthesia; female; human; major clinical study; mood disorder; pregnancy; priority journal; psychometry; puerperal psychosis; puerperium; questionnaire, Adult; Affect; Delivery, Obstetric; Depression, Postpartum; Female; Humans; Interleukin-6; Middle Aged; Personality Inventory; Pregnancy; Psychometrics; Tumor Necrosis Factor-alpha; Young Adult
DOI:
10.1016/j.jad.2008.07.008
