Τίτλος:
Slight and short-lasting increase of serum S-100B protein in extra-cranial trauma
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: Serum S-100B protein is an established biochemical marker of traumatic brain injury. At the same time, the question of extra-cranial S-100B release has been raised. This study evaluates the post-traumatic and post-operative release kinetics of S-100B in 45 trauma victims without head injury. Method: Serum S-100B protein was measured on admission and every 24 hours for 4 consecutive days. Results: Initial S-100B was slightly increased (median: 0.54 μg L-1) and correlated with the severity of extra-cranial trauma (p = 0.0004, Mann-Whitney test). Both severely (abdominal or chest trauma with or without bone fractures) and mildly (long bone fractures) injured showed a rapid decline of S-100B (<0.2 μg L-1) around 72 hours post-trauma. Extra-cranial surgery caused a secondary increase of S-100B, especially in the mildly injured group (p = 0.004, Wilcoxon signed rankest). Conclusions: Extra-cranial injury results in a mild elevation of serum S-100B protein that declines rapidly (1-3 days after injury).
Συγγραφείς:
Korfias, S.
Stranjalis, G.
Psachoulia, C.
Vasiliadis, C.
Pitaridis, M.
Boviatsis, E.
Sakas, D.E.
Περιοδικό:
Brain Injury Journey Magazine
Εκδότης:
Informa Healthcare
Λέξεις-κλειδιά:
biological marker; protein S100B, abdominal injury; adult; aged; article; controlled study; correlation analysis; female; fracture; human; injury severity; major clinical study; male; postoperative period; protein blood level; protein secretion; rank sum test; surgical injury; thorax injury; traumatic brain injury; Wilcoxon signed ranks test
DOI:
10.1080/02699050600832395
