Τίτλος:
Motor and language deficits correlate with resting state functional magnetic resonance imaging networks in patients with brain tumors
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background and purpose: Evidence of pre-operative resting state functional magnetic resonance (RS-fMRI) validation by correlating it with clinical pre-operative status in brain tumor patients is scarce. Our aim was to validate the functional relevance of RS-fMRI by investigating the association between RS-fMRI and pre-operative motor and language function performance in patients with brain tumor. Materials and methods: Sixty-nine patients with brain tumors were prospectively recruited. Patients with tumors near precentral gyrus (n = 49) underwent assessment for apparent (paresis) and subtle (finger tapping) deficits. Patients with left frontal tumors in the vicinity of the inferior frontal gyrus (n = 29) underwent assessment for gross (aphasia) and mild language (phonological verbal fluency) deficits. RS-fMRI results were extracted by spatial independent component analysis (ICA). Results: Motor group: paretic patients showed significantly (P = 0.01) decreased BOLD signal in ipsilesional precentral gyrus when compared to contralesional one. Significantly (P < 0.01) lower BOLD signal was also observed in ipsilesional precentral gyrus of paretics when compared with the non-paretics. In asymptomatic patients, a strong positive correlation (r = 0.68, P < 0.01) between ipsilesional motor cortex BOLD signal and contralesional finger tapping performance was observed. Language group: patients with aphasia showed significantly (P = 0.01) decreased RS-fMRI BOLD signal in left BA 44 when compared with non- aphasics. In asymptomatic patients, a strong positive correlation (r = 0.72, P < 0.01) between BA 44 BOLD signal and phonological fluency performance was observed. Conclusions: Our results showed that RS-fMRI BOLD signal of motor and language networks were significantly affected by the tumors implying the usefulness of the method for assessment of the underlying functions in brain tumors patients. © 2018 Elsevier Masson SAS
Συγγραφείς:
Liouta, E.
Katsaros, V.K.
Stranjalis, G.
Leks, E.
Klose, U.
Bisdas, S.
Περιοδικό:
Journal de Neuroradiologie / Journal of Neuroradiology
Εκδότης:
Elsevier Masson SAS
Λέξεις-κλειδιά:
adult; aged; aphasia; Article; BOLD signal; brain tumor; correlation analysis; female; finger tapping test; functional magnetic resonance imaging; human; independent component analysis; language ability; language disability; major clinical study; male; medical assessment; motor dysfunction; paresis; primary motor cortex; prospective study; tumor localization; adolescent; brain mapping; brain tumor; diagnostic imaging; language disability; middle aged; motor dysfunction; nuclear magnetic resonance imaging; pathophysiology; procedures, Adolescent; Adult; Aged; Brain Mapping; Brain Neoplasms; Female; Humans; Language Disorders; Magnetic Resonance Imaging; Male; Middle Aged; Motor Disorders; Prospective Studies
DOI:
10.1016/j.neurad.2018.08.002
