Τίτλος:
Comparative study of angiogenesis in thyroid glands with graves disease and Hashimoto's thyroiditis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Angiogenesis entails the sprouting of new vessels from pre-existing vasculature. In adults, angiogenesis occurs in the thyroid gland during disease processes such as hyperplastic goiter, Graves disease, thyroiditis, and cancer. In the present study multiple morphologic characteristics of microvessels were measured in and compared between 18 cases of Graves disease, 29 cases of Hashimoto's thyroiditis, and 15 control cases. All histologic sections were immunostained for CD31. Quantification of microvessel density (MVD), major axis length, minor axis length, area, perimeter and shape factor was performed by image analysis. MVD was increased significantly in both forms of autoimmune thyroid disease. Significantly higher values were found in Graves disease in comparison to Hashimoto's thyroiditis. In contrast, major axis length, minor axis length, and area had significantly higher values in Hashimoto's thyroiditis than in Graves disease. The statistical analysis revealed MVD as the unique significant morphometric factor discriminating the two autoimmune entities. Copyright © 2006 by Lippincott Williams & Wilkins.
Συγγραφείς:
Tseleni-Balafouta, S.
Kavantzas, N.
Balafoutas, D.
Patsouris, E.
Περιοδικό:
Applied Immunohistochemistry and Molecular Morphology
Λέξεις-κλειδιά:
angiogenesis; article; autoimmune disease; cancer; controlled study; goiter; Graves disease; Hashimoto disease; human; human tissue; immunohistochemistry; microvasculature; priority journal; statistical analysis; thyroid gland; thyroiditis, Adult; Aged; Antigens, CD31; Female; Graves Disease; Hashimoto Disease; Humans; Immunohistochemistry; Male; Middle Aged; Neovascularization, Pathologic; Thyroid Gland
DOI:
10.1097/01.pai.0000174262.33385.5e
