Τίτλος:
Diet-induced hypothalamic inflammation, phoenixin, and subsequent precocious puberty
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Recent studies have shown a rise in precocious puberty, especially in girls. At the same time, childhood obesity due to overnutrition and energy imbalance is rising too. Nutrition and fertility are currently facing major challenges in our societies, and are interconnected. Studies have shown that high-fat and/or high-glycaemic-index diet can cause hypothalamic inflammation and microglial activation. Molecular and animal studies reveal that microglial activation seems to produce and activate prostaglandins, neurotrophic factors activating GnRH (gonadotropin-releasing hormone expressing neurons), thus initiating precocious puberty. GnRH neurons’ mechanisms of excitability are not well understood. In this review, we study the phenomenon of the rise of precocious puberty, we examine the physiology of GnRH neurons, and we review the recent literature regarding the pathophysiological mechanisms that connect diet-induced hypothalamic inflammation and diet-induced phoenixin regulation with precocious puberty. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Valsamakis, G.
Arapaki, A.
Balafoutas, D.
Charmandari, E.
Vlahos, N.F.
Περιοδικό:
Nutrient Cycling in Agroecosystems
Λέξεις-κλειδιά:
carbon tetrachloride; gonadorelin; biological marker; peptide hormone, central precocious puberty; high glycemic index diet; human; hypothalamus; inflammation; lipid diet; microglia; pathophysiology; peripheral precocious puberty; precocious puberty; puberty; Review; adverse event; animal; complication; diet; disease predisposition; encephalitis; metabolism; pathology; precocious puberty, Animals; Biomarkers; Diet; Disease Susceptibility; Encephalitis; Humans; Hypothalamus; Peptide Hormones; Puberty, Precocious
