Τίτλος:
Risk evaluation of vitamin D insufficiency or deficiency in children using simple scores: The Healthy Growth Study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Although identification of population groups at high risk for low vitamin D status is of public health importance,there are no risk prediction tools available for children in Southern Europe that can cover this need. The present study aimed to develop and validate 2 simple scores that evaluate the risk for vitamin D insufficiency or deficiency in children. A cross-sectional epidemiological study was conducted among 2280 schoolchildren (9–13-year-old) living in Greece. The total sample was randomly divided into 2 subsamples of 1524 and 756 children, used in the development and validation of the 2 scores, respectively. Multivariate logistic regression analyses were used to develop the 2 risk evaluation scores, while receiver operating characteristic curves were employed to identify the optimal “points of change” for each risk score, upon which vitamin D insufficiency and deficiency is diagnosed with the highest possible sensitivity and specificity. The components of the 2 risk evaluation scores included children's age, gender, region of residence, screen-time, body weight status, maternal education, and season. The increase in each score by 1 unit elevated the likelihood for vitamin D insufficiency and deficiency by 31% and 28%, respectively. The receiver operating characteristic curves showed that the optimal “points of change” for each risk score, upon which vitamin D insufficiency or deficiency is diagnosed with the highest possible sensitivity and specificity were 8.5 and 12.5, respectively. In conclusion, this study developed 2 simple scores that evaluate the risk for vitamin D insufficiency or deficiency in children living in Greece. However, more studies are required for these scores to be validated in other populations of children from different countries. © 2020
Συγγραφείς:
Moschonis, G.
Androutsos, O.
Hulshof, T.
Sarapis, K.
Dracopoulou, M.
Chrousos, G.P.
Manios, Y.
Περιοδικό:
Nutrition Research
Εκδότης:
ELSEVIER SCIENCE INC 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
Λέξεις-κλειδιά:
age; Article; body weight; child; cohort analysis; controlled study; cross-sectional study; disease assessment; educational status; epidemiological data; female; gender; Greece; human; major clinical study; male; maternal attitude; program development; receiver operating characteristic; residential area; risk assessment; school child; screen time; seasonal variation; sensitivity and specificity; study design; validation process; vitamin D deficiency; adolescent; blood; bone development; physiology; risk factor; season; socioeconomics; vitamin D deficiency, 25-hydroxyvitamin D; vitamin D, Adolescent; Bone Development; Child; Female; Greece; Humans; Male; Risk Factors; ROC Curve; Screen Time; Seasons; Socioeconomic Factors; Vitamin D; Vitamin D Deficiency
DOI:
10.1016/j.nutres.2020.12.021
