Τίτλος:
The role of hypothalamic inflammation in diet-induced obesity and its association with cognitive and mood disorders
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Obesity is often associated with cognitive and mood disorders. Recent evidence suggests that obesity may cause hypothalamic inflammation. Our aim was to investigate the hypothesis that there is a causal link between obesity-induced hypothalamic inflammation and cognitive and mood disorders. Inflammation may influence hypothalamic inter-connections with regions important for cognition and mood, while it may cause dysregulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis and influence monoaminergic systems. Exercise, healthy diet, and glucagon-like peptide receptor agonists, which can reduce hypothalamic inflammation in obese models, could improve the deleterious effects on cognition and mood. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Dionysopoulou, S.
Charmandari, E.
Bargiota, A.
Vlachos, N.
Mastorakos, G.
Valsamakis, G.
Περιοδικό:
Nutrient Cycling in Agroecosystems
Λέξεις-κλειδιά:
glucagon like peptide 1 receptor agonist; glucagon like peptide receptor, cognitive defect; diet-induced obesity; disease association; exercise; healthy diet; human; hypothalamus; hypothalamus hypophysis adrenal system; monoaminergic system; mood disorder; nervous system inflammation; nonhuman; pathophysiology; Review; signal transduction; systematic review; adverse event; animal; cognitive defect; complication; diet; hypophysis adrenal system; hypothalamus disease; hypothalamus hypophysis system; inflammation; mood disorder; obesity, Animals; Cognition Disorders; Diet; Diet, Healthy; Exercise; Glucagon-Like Peptide Receptors; Humans; Hypothalamic Diseases; Hypothalamo-Hypophyseal System; Inflammation; Mood Disorders; Obesity; Pituitary-Adrenal System
