Τίτλος:
Longitudinal study on novel neuropeptides phoenixin, spexin and kisspeptin in adolescent inpatients with anorexia nervosa–association with psychiatric symptoms
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objectives: It is hypothesized that novel neuropeptides such as phoenixin (PNX), spexin (SPX), and kisspeptin (KISS) are involved in the pathogenesis of eating disorders. The study presented here analyzed neuropeptide concentrations during the course of anorexia nervosa (AN) and aimed to correlate those values with anthropometric and psychometric measurements. Methods: A longitudinal study was carried outin 30 AN adolescent patients and 15 age-matched healthy female controls. Selected neuroprotein serum levels were analyzed in malnourished patients (accAN) and following partial weight recovery (norAN), and these values were compared with the control group. Results: In accAN patients, decreased serum PNX levels were detected while SPX serum concentrations were lower in the accAN and norAN patients. No differences were observed in KISS concentrations in all studied groups. Conclusions: In malnourished adolescent inpatients with AN, serum PNX and SPX level were decreased. The partial weight recovery normalized PNX concentrations but failed to normalize SPX levels. Therefore these two neuropeptides might be crucial for the etiology and course of the AN. The KISS levels did not change in the course of AN. The PNX levels were associated with some symptoms of eating disorders which may indicate its potential contribution in the regulation of emotions and behaviors in AN. © 2019 Informa UK Limited, trading as Taylor & Francis Group.
Συγγραφείς:
Pałasz, A.
Tyszkiewicz-Nwafor, M.
Suszka-Świtek, A.
Bacopoulou, F.
Dmitrzak-Węglarz, M.
Dutkiewicz, A.
Słopień, A.
Janas-Kozik, M.
Wilczyński, K.M.
Filipczyk, Ł.
Bogus, K.
Rojczyk, E.
Paszyńska, E.
Wiaderkiewicz, R.
Περιοδικό:
Nutritional Neuroscience
Εκδότης:
Taylor and Francis Ltd.
Λέξεις-κλειδιά:
alanine aminotransferase; aspartate aminotransferase; carbon tetrachloride; creatinine; glucose; high density lipoprotein; insulin; kisspeptin; liothyronine; low density lipoprotein; neuropeptide; potassium; sodium; spexin; thyrotropin; thyroxine; triacylglycerol; unclassified drug, adolescent; amenorrhea; anorexia nervosa; Article; Beck Depression Inventory; blood cell count; body mass; body weight gain; caloric intake; clinical article; controlled study; DSM-5; DSM-IV; Eating Attitudes Test; eating disorder; enzyme linked immunosorbent assay; female; hospital patient; human; ICD-10; longitudinal study; malnutrition; menstruation; mental disease; partial weight recovery; questionnaire; urea nitrogen blood level; Yale Brown Obsessive Compulsive Scale
DOI:
10.1080/1028415X.2019.1692494
