Περίληψη:
Deficiencies in vitamin D, folate and cobalamin are common in Inflammatory Bowel Disease (IBD). The aim of the present study was to assess serum levels of these vitamins in IBD adults based on the respective serum cut off values for vitamin deficiencies, and to explore possible associations with IBD-related biomarkers and nutritional intake. A cross-sectional study was carried out and patients with Crohn’s disease (CD) or ulcerative colitis (UC) from Attica-Greece were enrolled. Medical and dietary history, clinical examination and blood/stool biomarkers were evaluated. In total, 87 patients participated in the study. Serum levels of 25(OH)D, folate and cobalamin were deficient in 36.8%, 18.4% and 5.7% of patients, respectively. Linear regression analysis in the overall patients showed positive associations between (a) serum 25(OH)D with serum iron (beta = 0.083, p = 0.005) and (b) serum cobalamin with total bilirubin (beta = 0.357, p = 0.020) and direct bilirubin (beta = 0.727, p = 0.033), adjusting for age, sex, body mass index (BMI), disease activity and duration, smoking, nutritional intake and season of recruitment. In CD patients (N = 54), a negative linear association between serum folate and fecal lysozyme was evident (beta = −0.009, p = 0.020). No associations were found for UC patients (N = 33). The serum vitamin profile may be a complementary biomarker for the evaluation of disease activity next to serum and stool inflammatory biomarkers. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Gioxari, A.
Amerikanou, C.
Papada, E.
Zioga, E.
Georgoulis, A.D.
Bamias, G.
Kaliora, A.C.
Λέξεις-κλειδιά:
bilirubin; bilirubin glucuronide; cyanocobalamin; folic acid; iron; lysozyme; vitamin D; bilirubin; biological marker; cyanocobalamin; folic acid; vitamin D, adult; age; Article; B12 deficiency; blood analysis; body mass; clinical examination; colorimetry; controlled study; Crohn disease; cross-sectional study; dietary intake; disease activity; disease duration; feces analysis; female; folic acid blood level; folic acid deficiency; Greece; Greek (citizen); human; human tissue; inflammatory bowel disease; iron blood level; major clinical study; male; medical history; oxidative stress; sandwich ELISA; sex; smoking; turbidimetry; ulcerative colitis; vitamin blood level; vitamin D deficiency; blood; inflammatory bowel disease; middle aged; nutritional status; season, Adult; Bilirubin; Biomarkers; Colitis, Ulcerative; Crohn Disease; Cross-Sectional Studies; Female; Folic Acid; Folic Acid Deficiency; Greece; Humans; Inflammatory Bowel Diseases; Male; Middle Aged; Nutritional Status; Oxidative Stress; Seasons; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin D; Vitamin D Deficiency
