Τίτλος:
Association between lipids and apolipoproteins on type 2 diabetes risk; moderating effects of gender and polymorphisms; the ATTICA study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background and aims: Type 2 diabetes mellitus (T2DM) is a condition defined by hyperglycaemia, but also often presents with dyslipidaemia and suppressed HDL cholesterol. Mendelian randomization studies have suggested a causal link between low HDL cholesterol and T2DM. However, influences of gender, polymorphisms and lifestyle, all known to influence HDL cholesterol, have not been fully explored in a prospective cohort. Methods and results: In 2001–2002, a random sample of 1514 males (18–87 years old) and 1528 females (18–89 years old) were recruited in the ATTICA study. The 10-year follow-up (2011–2012) included 1485 participants. Lipids and lipoproteins levels, glucose and insulin levels were measured together with apolipoprotein A1 (apoA1) 75 G/A genotype, which is known to influence HDL-cholesterol. In total, 12.9% of the study sample developed T2DM within the 10-year follow-up period. In multivariable models, for each mg/dL increase in apoA1 levels in males, 10-year T2DM risk decreased 1.02%; while every unit increase in apoB/LDL-cholesterol ratio increased risk 4-fold. Finally, for every unit increase in triglycerides/apoA1 ratio, the risk increased 85%. HOMA-IR independently predicted T2DM 10-year incidence only for carriers of GG polymorphism (all, p < 0.05), but not in carriers of the GA polymorphism (all, p > 0.05). Conclusion: ApoA1 was associated with decreased T2DM risk and TG/ApoA1 and apoB/LDL were associated with increased risk of T2DM, only in males. ApoA1 polymorphism, which is associated with lower HDL cholesterol, influenced the predictive effects of HOMA-IR on T2DM incidence, which appeared to be moderated by physical activity, suggesting potential scope for more targeted preventative strategies. © 2020 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University
Συγγραφείς:
Mellor, D.D.
Georgousopoulou, E.N.
D'Cunha, N.M.
Naumovski, N.
Chrysohoou, C.
Tousoulis, D.
Pitsavos, C.
Panagiotakos, D.B.
the ATTICA Study Group
Περιοδικό:
Nutrition, Metabolism and Cardiovascular Diseases
Λέξεις-κλειδιά:
apolipoprotein; apolipoprotein A1; apolipoprotein B; cholesterol; genomic DNA; high density lipoprotein cholesterol; insulin; lipid; low density lipoprotein cholesterol; triacylglycerol; APOA1 protein, human; APOB protein, human; apolipoprotein A1; apolipoprotein B100; biological marker; high density lipoprotein cholesterol; lipid; low density lipoprotein cholesterol; triacylglycerol, adult; aged; Article; body height; body weight; DNA extraction; family history; follow up; gender; genetic association; genetic polymorphism; genotype; glucose blood level; health survey; homeostasis model assessment; hospital admission; human; immunoturbidimetry; insulin resistance; international physical activity questionnaire; major clinical study; male; non insulin dependent diabetes mellitus; physical activity; polymerase chain reaction; priority journal; radioimmunoassay; restriction fragment length polymorphism; risk factor; sedentary lifestyle; single nucleotide polymorphism; smoking; adolescent; blood; dyslipidemia; female; genetic predisposition; genetics; Greece; middle aged; non insulin dependent diabetes mellitus; nutrition; prognosis; prospective study; risk assessment; risk factor; sex factor; time factor; very elderly; young adult, Adolescent; Adult; Aged; Aged, 80 and over; Apolipoprotein A-I; Apolipoprotein B-100; Biomarkers; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Dyslipidemias; Female; Genetic Predisposition to Disease; Greece; Humans; Lipids; Male; Middle Aged; Nutrition Surveys; Polymorphism, Genetic; Prognosis; Prospective Studies; Risk Assessment; Risk Factors; Sex Factors; Time Factors; Triglycerides; Young Adult
DOI:
10.1016/j.numecd.2020.01.008
