Περίληψη:
Purpose: Coffee and tea constituents have shown several anti-carcinogenic activities in cellular and animal studies, including against thyroid cancer (TC). However, epidemiological evidence is still limited and inconsistent. Therefore, we aimed to investigate this association in a large prospective study. Methods: The study was conducted in the EPIC (European Prospective Investigation into Cancer and Nutrition) cohort, which included 476,108 adult men and women. Coffee and tea intakes were assessed through validated country-specific dietary questionnaires. Results: During a mean follow-up of 14 years, 748 first incident differentiated TC cases (including 601 papillary and 109 follicular TC) were identified. Coffee consumption (per 100 mL/day) was not associated either with total differentiated TC risk (HRcalibrated 1.00, 95% CI 0.97–1.04) or with the risk of TC subtypes. Tea consumption (per 100 mL/day) was not associated with the risk of total differentiated TC (HRcalibrated 0.98, 95% CI 0.95–1.02) and papillary tumor (HRcalibrated 0.99, 95% CI 0.95–1.03), whereas an inverse association was found with follicular tumor risk (HRcalibrated 0.90, 95% CI 0.81–0.99), but this association was based on a sub-analysis with a small number of cancer cases. Conclusions: In this large prospective study, coffee and tea consumptions were not associated with TC risk. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
Συγγραφείς:
Zamora-Ros, R.
Alghamdi, M.A.
Cayssials, V.
Franceschi, S.
Almquist, M.
Hennings, J.
Sandström, M.
Tsilidis, K.K.
Weiderpass, E.
Boutron-Ruault, M.-C.
Hammer Bech, B.
Overvad, K.
Tjønneland, A.
Petersen, K.E.N.
Mancini, F.R.
Mahamat-Saleh, Y.
Bonnet, F.
Kühn, T.
Fortner, R.T.
Boeing, H.
Trichopoulou, A.
Bamia, C.
Martimianaki, G.
Masala, G.
Grioni, S.
Panico, S.
Tumino, R.
Fasanelli, F.
Skeie, G.
Braaten, T.
Lasheras, C.
Salamanca-Fernández, E.
Amiano, P.
Chirlaque, M.-D.
Barricarte, A.
Manjer, J.
Wallström, P.
Bueno-de-Mesquita, H.B.
Peeters, P.H.
Khaw, K.-T.
Wareham, N.J.
Schmidt, J.A.
Aune, D.
Byrnes, G.
Scalbert, A.
Agudo, A.
Rinaldi, S.
Λέξεις-κλειδιά:
adult; aged; anaplastic thyroid carcinoma; Article; cancer risk; coffee; cohort analysis; differentiated thyroid cancer; disease association; female; follow up; human; lymphoma; major clinical study; male; prospective study; tea; thyroid follicular carcinoma; thyroid medullary carcinoma; thyroid papillary carcinoma; adenocarcinoma; clinical trial; Europe; middle aged; multicenter study; nutritional assessment; questionnaire; risk; thyroid tumor, Adenocarcinoma, Papillary; Adult; Aged; Coffee; Cohort Studies; Europe; Female; Humans; Male; Middle Aged; Nutrition Assessment; Prospective Studies; Risk; Surveys and Questionnaires; Tea; Thyroid Neoplasms
