Τίτλος:
Serum antioxidant capacity, biochemical profile and body composition of breast cancer survivors in a randomized Mediterranean dietary intervention study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: Increasing evidence suggests that Mediterranean Diet (MD) is correlated with reduced risk of breast cancer (BC) and cancer mortality, since it modifies patients’ serum antioxidant capacity, body composition and biochemical parameters. The aim of the study was to investigate whether a dietary intervention based on MD has a beneficial effect on these factors. Methods: In this intervention study, seventy female BC survivors were randomly assigned to (1) the intervention group (personalized dietary intervention based on MD) and (2) the control group (received the updated American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention and ad libitum diet). Both groups were assessed twice [beginning, end of study (after 6 months)] regarding their anthropometric and biochemical parameters, serum vitamin C, vitamin A, a-tocopherol and CoQ10 levels, dietary intake and adherence to MD. An additional intermediate analysis was conducted on participants’ body composition and biochemical profile. Results: Concerning the intervention group, body weight, body fat mass, waist circumference, body mass index as well as HDL-cholesterol were significantly decreased (P < 0.2%). An increase was observed in the vitamin C levels in blood (P < 0.2%). In the control group, body weight, body fat mass and serum total cholesterol rose (P < 0.2%). At the end of the study the two groups were significantly different considering blood glucose, vitamin C, polyunsaturated fatty acids, vitamin A and a-tocopherol levels. Conclusions: This randomized dietary intervention based on MD managed to ameliorate serum antioxidant capacity, body composition, adherence to MD and glycemic profile of postmenopausal BC survivors. © 2017, Springer-Verlag GmbH Germany.
Συγγραφείς:
Skouroliakou, M.
Grosomanidis, D.
Massara, P.
Kostara, C.
Papandreou, P.
Ntountaniotis, D.
Xepapadakis, G.
Περιοδικό:
European Journal of Nutrition
Εκδότης:
Dr. Dietrich Steinkopff Verlag GmbH and Co. KG
Λέξεις-κλειδιά:
alpha tocopherol; ascorbic acid; glucose; high density lipoprotein cholesterol; retinol; ubidecarenone; antioxidant, adult; Article; body composition; body fat; body mass; body weight; breast cancer; cancer chemotherapy; cancer hormone therapy; cancer radiotherapy; cancer survivor; cholesterol blood level; clinical article; controlled study; dietary intake; fat mass; female; glucose blood level; human; intervention study; Mediterranean diet; patient compliance; physical activity; postmenopause; randomized controlled trial; smoking habit; vitamin blood level; waist circumference; body mass; breast tumor; Greece; metabolism; middle aged, Antioxidants; Body Composition; Body Mass Index; Breast Neoplasms; Cancer Survivors; Diet, Mediterranean; Female; Greece; Humans; Middle Aged
DOI:
10.1007/s00394-017-1489-9
