Τίτλος:
Vascular inflammation and metabolic activity in hematopoietic organs and liver in familial combined hyperlipidemia and heterozygous familial hypercholesterolemia
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Familial dyslipidemias of either heterozygous (heFH) or combined (FCH) type lead to accelerated atherogenesis and increased cardiovascular risk. Objective: The aim of this study was to investigate in statin-naïve adult patients with familial dyslipidemias whether inflammatory activation and liver, spleen and bone marrow metabolic activity differ compared with normolipidemic subjects and between dyslipidemic groups. Methods: Fourteen patients with FCH, 14 with heFH, and 14 normolipidemic individuals were enrolled. Serum lipids, high-sensitivity C-reactive protein, and fibrinogen levels were measured, followed by 18 F-fluorodeoxyglucose positron-emission tomography/computed tomography imaging. Radiotracer uptake in the aortic wall, spleen, bone marrow, and liver was quantified as tissue-to-background ratio (TBR). Results: Patients with heFH had significantly higher low-density lipoprotein levels compared with those with FCH and controls (P < .001). However, aortic TBRs were higher in FCH compared with heFH patients and controls (P = .02 and P < .001, respectively). FCH patients exhibited higher FDG uptake in the spleen compared with controls (P = .05). In addition, FCH exhibited higher bone marrow FDG uptake compared with heFH patients and controls (P = .03 and P = .02, respectively). FCH had higher liver uptake compared with heFH patients and controls (P < .001 for both). Significant correlations were observed between inflammatory biomarkers and imaging indices as well as between aortic TBR and FDG uptake of hematopoietic organs and liver. Conclusions: Systemic, as well as vascular inflammation and spleen, bone marrow, and hepatic metabolic activity are increased in patients with FCH despite lower levels of low-density lipoprotein. © 2017 National Lipid Association
Συγγραφείς:
Toutouzas, K.
Skoumas, J.
Koutagiar, I.
Benetos, G.
Pianou, N.
Georgakopoulos, A.
Galanakos, S.
Antonopoulos, A.
Drakopoulou, M.
Oikonomou, E.K.
Kafouris, P.
Athanasiadis, E.
Metaxas, M.
Spyrou, G.
Pallantza, Z.
Galiatsatos, N.
Aggeli, C.
Antoniades, C.
Keramida, G.
Peters, A.M.
Anagnostopoulos, C.D.
Tousoulis, D.
Περιοδικό:
Journal of Clinical Lipidology
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
C reactive protein; fibrinogen; fluorodeoxyglucose f 18; low density lipoprotein; triacylglycerol; biological marker; C reactive protein; hydroxymethylglutaryl coenzyme A reductase inhibitor; low density lipoprotein, adult; aortic wall; arterial inflammation; artery disease; Article; bone marrow; clinical article; controlled study; familial hypercholesterolemia; familial hyperlipemia; female; hematopoietic system; heterozygous familial hypercholesterolemia; homeostasis model assessment; human; lipid blood level; liver; male; measurement; metabolism; positron emission tomography-computed tomography; priority journal; prospective study; spleen; vasculitis; blood; case control study; diagnostic imaging; familial hypercholesterolemia; familial hyperlipemia; heterozygote; inflammation; liver; middle aged; pathology, Adult; Biomarkers; Bone Marrow; C-Reactive Protein; Case-Control Studies; Female; Heterozygote; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemia, Familial Combined; Hyperlipoproteinemia Type II; Inflammation; Lipoproteins, LDL; Liver; Male; Middle Aged; Positron Emission Tomography Computed Tomography; Spleen
DOI:
10.1016/j.jacl.2017.10.019
