Τίτλος:
Glycemic load and coronary heart disease in a Mediterranean population: The EPIC Greek cohort study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background and aims: High glycemic load (GL) has been associated with increased coronary heart disease (CHD) risk. We evaluated whether preference of low-GL foods conveys incremental benefits with respect to CHD, especially to people adhering to the traditional Mediterranean diet (MD). Methods and results: We analyzed data from the Greek European Prospective Investigation into Cancer and Nutrition, including 20,275 participants free of cardiovascular diseases, cancer, or diabetes at baseline and without incident diabetes. Subjects completed a validated, semi-quantitative food frequency questionnaire at enrollment. We calculated a 10-point MD adherence score and the dietary GL, and estimated hazard ratios (HRs) for CHD incidence and mortality through Cox proportional hazard regression. After a median follow-up of 10.4 years, 417 participants developed CHD, and 162 died from the disease. A significant positive association of GL with CHD incidence emerged (HR for the highest versus the lowest tertile=1.41, 95% confidence interval, CI: 1.05-1.90). HRs for CHD mortality exceeded unity but were not statistically significant. The association with GL was stronger among subjects with higher body mass index. High adherence to MD with low/moderate GL was associated with lower risk of CHD incidence (HR = 0.61, CI: 0.39-0.95) and mortality (HR = 0.47, 95% CI: 0.23-96). Conclusion: High dietary GL increases the risk of CHD. Compared to a high GL diet with suboptimal adherence to the traditional Mediterranean pattern, a low/moderate GL diet that also conforms to the traditional MD principles could lead to a 40% reduced risk for CHD, and over 50% reduced risk for death from CHD. © 2014 Elsevier B.V..
Συγγραφείς:
Turati, F.
Dilis, V.
Rossi, M.
Lagiou, P.
Benetou, V.
Katsoulis, M.
Naska, A.
Trichopoulos, D.
La Vecchia, C.
Trichopoulou, A.
Περιοδικό:
Nutrition, Metabolism and Cardiovascular Diseases
Λέξεις-κλειδιά:
adult; aged; Article; body mass; cardiovascular mortality; cardiovascular risk; cohort analysis; dietary intake; female; follow up; food frequency questionnaire; glycemic load; human; ischemic heart disease; male; Mediterranean diet; priority journal; prospective study; scoring system; Caucasian; coronary artery disease; diet therapy; feeding behavior; Greece; incidence; middle aged; mortality; nutritional status; proportional hazards model; questionnaire; risk factor; very elderly; young adult, Adult; Aged; Aged, 80 and over; Coronary Disease; Diet, Mediterranean; European Continental Ancestry Group; Female; Follow-Up Studies; Food Habits; Glycemic Load; Greece; Humans; Incidence; Male; Middle Aged; Nutritional Status; Proportional Hazards Models; Prospective Studies; Risk Factors; Surveys and Questionnaires; Young Adult
DOI:
10.1016/j.numecd.2014.12.002
