Τίτλος:
Beneficial health effects of Chios Gum Mastic and Peroxisome proliferator-Activated receptors: Indications of common mechanisms
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
For thousands of years, Chios Gum Mastic (CGM), the resin produced by the trunk of Pistachia lentiscus var Chia, has been used for culinary and medicinal purposes and several therapeutic properties have been attributed to it. CGM has been used in traditional medicine of various nations in the eastern Mediterranean area. This survey was carried out to identify biological mechanisms that could explain traditional usage and recent pharmacological findings. We reviewed the related scientific literature available from the NCBI PUBMED database on CGM studies and on natural products showing peroxisome proliferator-Activated receptor (PPAR) agonist effects. We investigated whether CGM qualifies as a PPAR modulator. A large number of studies demonstrate that CGM has antioxidant, anti-inflammatory, hypolipidemic, and anticancer properties. Recently, the first evidence of CGM antidiabetic effect became known. CGM chemical composition has been extensively analyzed and the presence of several compounds, especially triterpenoids is well documented. Some of them, oleanonic acid, oleanolic acid, and gallic acid are considered to act as PPAR modulators. PPARs are nuclear receptors functioning as transcription factors and thereby controlling cellular functions at the level of gene expression. PPARs are involved in the pathways of significant diseases, such as metabolic syndrome, diabetes mellitus, dyslipidemia, inflammation, atheromatosis, and neoplasias, constituting a key target for pharmacological interventions. This article proposes that the synergistic action of some constituents of CGM on PPARs and more precisely on both PPARs isotypes-α and -γ, may be one of the major biological mechanisms via which CGM exerts its multiple effects. © Copyright 2015, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2015.
Συγγραφείς:
Georgiadis, I.
Karatzas, T.
Korou, L.-M.
Katsilambros, N.
Perrea, D.
Περιοδικό:
Journal of Medicinal Food
Εκδότης:
Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA
Λέξεις-κλειδιά:
amino acid; antiinflammatory agent; antineoplastic agent; antioxidant; cell nucleus receptor; chios gum mastic; gallic acid; oleanolic acid; oleanonic acid; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor agonist; peroxisome proliferator activated receptor alpha; peroxisome proliferator activated receptor delta; peroxisome proliferator activated receptor gamma; resin; transcription factor; triterpenoid; unclassified drug; antidiabetic agent; antiinflammatory agent; antilipemic agent; antineoplastic agent; gum mastic; peroxisome proliferator activated receptor; plant extract; plant resin; transcription factor; triterpene, antidiabetic activity; antiinflammatory activity; antineoplastic activity; antioxidant activity; atheromatosis; biological activity; cell function; chemical composition; diabetes mellitus; drug indication; drug mechanism; dyslipidemia; gene expression; glucose metabolism; human; hypolipemia; inflammation; inflammatory bowel disease; lipid metabolism; medicinal plant; metabolic syndrome X; neoplasm; nonhuman; Pistachia; Pistachia lentiscus; priority journal; Review; traditional medicine; animal; chemistry; metabolism; phytotherapy; Pistacia, Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Peroxisome Proliferator-Activated Receptors; Phytotherapy; Pistacia; Plant Extracts; Resins, Plant; Transcription Factors; Triterpenes
DOI:
10.1089/jmf.2014.0021
