Soluble receptor for advanced glycation end-product levels are related to albuminuria and arterial stiffness in essential hypertension

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:2988539 13 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Soluble receptor for advanced glycation end-product levels are related to albuminuria and arterial stiffness in essential hypertension
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background and aims: Emerging evidence suggests that the soluble receptor for advanced glycation end-products (sRAGE) is implicated in the development of vascular disease. We investigated the interrelationships of sRAGE with albumin to creatinine ratio (ACR) and arterial stiffness in essential hypertension. Methods and results: In 309 untreated non-diabetic hypertensives, ACR values were determined as the mean of three non-consecutive morning spot urine samples and aortic stiffness was evaluated on the basis of carotid to femoral pulse wave velocity (c-f PWV). In all subjects, venous blood sampling was performed for the estimation of sRAGE levels. Patients with low (n = 155) compared to those with high sRAGE values (n = 154) had greater 24-h systolic BP (140 ± 8 vs. 134 ± 7 mmHg, p < 0.0001), exhibited higher ACR (36.3 ± 51.6 vs. 17.2 ± 1.2 mg g-1, p < 0.0001) and c-f PWV (8.3 ± 1.5 vs. 7.8 ± 1.1 m s-1, p = 0.003), independently of confounding factors. Multiple regression analyses revealed that age, male sex, 24-h systolic BP and sRAGE were the 'independent correlates' of ACR (R2 = 0.493, p < 0.0001), while age, 24-h systolic BP and sRAGE were the 'independent correlates' of c-f PWV (R2 = 0.428, p < 0.0001). Conclusion: In hypertensives, decreased sRAGE levels are accompanied by pronounced albuminuria and arterial stiffening. The association of sRAGE with ACR and c-f PWV suggests involvement of sRAGE in the progression of hypertensive vascular damage. © 2011 Elsevier B.V.
Έτος δημοσίευσης:
2013
Συγγραφείς:
Dimitriadis, K.
Tsioufis, C.
Kasiakogias, A.
Miliou, A.
Poulakis, M.
Kintis, K.
Bafakis, I.
Benardis, E.
Tousoulis, D.
Stefanadis, C.
Περιοδικό:
Nutrition, Metabolism and Cardiovascular Diseases
Τόμος:
23
Αριθμός / τεύχος:
4
Σελίδες:
382-388
Λέξεις-κλειδιά:
advanced glycosylation end product receptor; advanced glycosylation end-product receptor; biological marker; creatinine; immunoglobulin receptor, adult; albuminuria; analysis of variance; arterial stiffness; article; blood; blood pressure; cross-sectional study; disease course; down regulation; female; human; hypertension; male; middle aged; pathophysiology; predictive value; pulse wave; risk assessment; risk factor; statistical model; urine, Adult; Albuminuria; Analysis of Variance; Biological Markers; Blood Pressure; Creatinine; Cross-Sectional Studies; Disease Progression; Down-Regulation; Female; Humans; Hypertension; Linear Models; Male; Middle Aged; Predictive Value of Tests; Pulse Wave Analysis; Receptors, Immunologic; Risk Assessment; Risk Factors; Vascular Stiffness
Επίσημο URL (Εκδότης):
DOI:
10.1016/j.numecd.2011.10.003
Το ψηφιακό υλικό του τεκμηρίου δεν είναι διαθέσιμο.