Τίτλος:
Chemical composition and biological activities of Calamintha officinalis Moench essential oil
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Calamintha officinalis Moench essential oil is used in cooking as an aromatic herb and also to improve the flavor and fragrance of several pharmaceutical products. The essential oil, obtained by hydrodistillation (5 mL/kg), was analyzed by gas chromatography-mass spectrometry and gas chromatography-flame ionization detection. Sixty-four components were identified, constituting 99.7% of the total oil. The major component was found to be carvone (38.7%), followed by neo-dihydrocarveol (9.9%), dihydrocarveol acetate (7.6%), dihydrocarveol (6.9%), 1, 8 cineole (6.4%), cis-carvyl acetate (6.1%), and pulegone (4.1%). The essential oil showed antifungal and antimicrobial activity against Gram-positive bacteria. In addition, it presented a very low toxicity both in vivo (50% lethal dose >100 mg/kg) and in vitro in the Artemia salina test (50% lethal concentration >500 μL/mL). C. officinalis essential oil, in rodents, produces the typical effects in behavior of a nonselective central nervous system-depressant drug; it potentiates the hypnotic effects of sodium pentobarbital, decreasing the induction time and enhancing the sleeping time. Moreover, it produces a decrease in body temperature and a protection against pentylenetetrazole-induced convulsions. Copyright 2011, Mary Ann Liebert, Inc.
Συγγραφείς:
Monforte, M.T.
Tzakou, O.
Nostro, A.
Zimbalatti, V.
Galati, E.M.
Περιοδικό:
Journal of Medicinal Food
Λέξεις-κλειδιά:
1 octen 3 ol; 3 octanol; 5,5 dimethyl 1,3 cyclohexanedione; beta elemene; beta pinene; bicyclogermacrene; borneol; bourbonene; camphene; camphor; carvone; cineole; copaene; diazepam; dihydrocarveol; epizonarene; essential oil; germacrene a; limonene; myrcene; ocimene; para cymene; pentobarbital; pinene; pulegone; sabinene; sabinene hydrate; terpinen 4 ol; terpinene; unclassified drug; unindexed drug, angiosperm; animal experiment; animal model; anticonvulsant activity; antifungal activity; antimicrobial activity; article; Calamintha officinalis; chemical composition; controlled study; drug potentiation; female; gas chromatography; in vitro study; in vivo study; male; mass fragmentography; mouse; nonhuman; priority journal; rat; tonic clonic seizure, Animals; Anti-Bacterial Agents; Anticonvulsants; Antifungal Agents; Artemia; Behavior, Animal; Body Temperature; Central Nervous System; Central Nervous System Depressants; Drug Synergism; Gram-Positive Bacteria; Hypnotics and Sedatives; Lamiaceae; Oils, Volatile; Pentobarbital; Pentylenetetrazole; Phytotherapy; Plant Extracts; Rats; Seizures; Sleep, Artemia salina; Calamintha sylvatica ascendens; Posibacteria; Rodentia
DOI:
10.1089/jmf.2009.0191
