Περίληψη:
Objective: To examine if wound aetiology has an effect on the pain-relieving properties of an ibuprofen-releasing foam dressing, which was previously shown to reduce pain inwounds of various aetiologies, compared with local best practice (LBP). Method: This was a secondary analysis of data from a multicentre, randomised, parallel group trial of patients with painful exuding wounds of various aetiologies. Wound aetiology was determinedatenrolment. Of 853 patients enrolled into the trial, 688 belonged to a wound aetiology subgroup that included > 25 patients and were included in the analysis reported here. Patients were randomised to a dressing containing 112.5mg of ibuprofen (ibuprofen foam) or to LBP for 5 days. Patients recorded pain relief and pain intensity daily. The main endpoint was the proportion of patients who, from day 1 to day 5, reported a summed pain reliefscore > 50% of the total maximum pain relief score (TOTPARD5>50%) and the corresponding number needed to treat (NNT) for each wound aetiology subgroup. Further analyses included the proportion of patients who, on a daily basis, reported pain relief > 50% of the maximum daily pain relief, the proportion of patients who, on day 5,experienced a reduction in pain intensity of > 50% of the maximum score (PIDD5>50%), and if PIDD5>50% was related to baseline pain intensity. Results: Patients were categorised by thefollowing five wound types: arterial, venous, and mixed arterial-venous leg ulcers, vasculitis and traumatic ulcers. The ibuprofenfoam dressing was associated with significantlygreater pain relief than LBP in all different wound aetiology subgroups, whether chronic or traumatic (acute). Overall, TOTPAR D5>50% was 55% in the ibuprofen foam group and 24% in the LBP group (p < 0.0001; NNT, 3.2). The pain intensity evaluations revealed similar results in favour ofibuprofen foam compared with LBP. No correlation was observed between PIDD5>50 and initial pain intensity. Conclusion: In this study, the ibuprofenfoam dressing was shown to consistently relievewound painin exuding wounds of various aetiologies, irrespective of basal painintensity.The data suggest that local pain reliefby an ibuprofenfoam dressing is possible in themost common, painful, exuding, chronic and acute/traumatic wounds and so is a safer alternative to systemic pain treatment. Conflict of interest: Of the ten authors involved inthe preparation of this manuscript, seven declare that theyhave no conflicts of interest. One is a member of the Wound AdvisoryForum for Coloplast A/S, Denmark. Two are employees of Coloplast A/S, Denmark.
Συγγραφείς:
Arapoglou, V.
Katsenis, K.
Syrigos, K.N.
Dimakakos, E.P.
Zakopoulou, N.
Tsoutsos, D.
Gjødsbøl, K.
Glynn, C.
Schäfer, E.
Petersen, B.
Λέξεις-κλειδιά:
ibuprofen; nonsteroid antiinflammatory agent, aged; article; clinical trial; female; human; injury; male; multicenter study; occlusive dressing; pain; randomized controlled trial (topic); regression analysis; skin ulcer; topical drug administration, Administration, Topical; Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Male; Occlusive Dressings; Pain; Randomized Controlled Trials as Topic; Regression Analysis; Skin Ulcer; Wounds and Injuries
