Τίτλος:
A double-blind, randomized clinical trial of the effect of ω-3 fatty acids on the oxidative stress of preterm neonates fed through parenteral nutrition
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background/Objectives: The aim of this study was to research and draw conclusions about the effect of a parenteral nutrition (PN) fat emulsion, rich in-ω3 fatty acids, on the antioxidant markers of preterm infants, when compared with a standard fat emulsion. This was a double-blind, parallel-group study conducted in Athens, Greece, using an equal randomization method. Subjects/Methods: Thirty-eight infants were selected using a double-blind method and a computer-generated randomization list. Both groups received PN, based on the same protocols. Group A received SMOFlipid fat emulsion, while group B received the standard fat emulsion (Intralipid). Serum levels of vitamin A, E and total antioxidant potential (TAP) were measured on days 0, 7 and 14 of PN support. Clinical and biochemical data were collected on days 0, 14 and on the day of discharge. Results: Serum levels of vitamin E and A were significantly increased in group A, while only vitamin A serum level was increased in group B on the fourteenth day (group A: vitamin E: P-value0.002, vitamin A: P-value0.000, group B: vitamin E: P-value0.065, vitamin A: P-value0.000). TAP was increased only in the intervention group (group A: P-value0.000, group B: P-value0.287). Mild anemia was developed in both groups, while no differences were detected in the infection rate, days of hospitalization, days of ventilator support and days of phototherapy. Conclusions: Oxidative stress was significantly reduced in those neonates fed with ω-3 fatty acids, whereas no effect was observed in the neonates fed with standard lipids. Intervention had no effect on infants growth and clinical outcome. © 2010 Macmillan Publishers Limited All rights reserved.
Συγγραφείς:
Skouroliakou, M.
Konstantinou, D.
Koutri, K.
Kakavelaki, C.
Stathopoulou, M.
Antoniadi, M.
Xemelidis, N.
Kona, V.
Markantonis, S.
Περιοδικό:
European Journal of Clinical Nutrition
Λέξεις-κλειδιά:
alpha tocopherol; bilirubin; C reactive protein; creatinine; intralipid; lipid emulsion; omega 3 fatty acid; retinol, absence of side effects; antioxidant activity; article; artificial ventilation; bilirubin blood level; biochemistry; body height; body temperature; body weight; child growth; clinical article; clinical examination; clinical trial; controlled clinical trial; controlled study; diastolic blood pressure; double blind procedure; Greece; head circumference; heart rate; hematocrit; hospital discharge; human; infant nutrition; length of stay; leukocyte count; newborn; oxidative stress; parenteral nutrition; phototherapy; prematurity; randomized controlled trial; systolic blood pressure; thrombocyte count; treatment duration; treatment outcome, Antioxidants; Double-Blind Method; Fat Emulsions, Intravenous; Fatty Acids, Omega-3; Female; Greece; Humans; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infant, Premature; Length of Stay; Male; Oxidation-Reduction; Oxidative Stress; Parenteral Nutrition; Treatment Outcome; Vitamin A; Vitamin E
DOI:
10.1038/ejcn.2010.98
