Τίτλος:
Antiproliferative activity of Greek propolis.
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The butanolic extract and the isolated chemical constituents, mainly diterpenes and flavonoids, from Greek propolis have been tested for their cytostatic activities against human malignant and normal cell strains. The extract and the diterpenes were found to be the most active against HT-29 human colon adenocarcinoma cells, without affecting normal human cells. Manool, a diterpene isolated for the first time from Greek propolis, was the most active compound, arresting the cancer cells at the G(2)/M phase of the cell cycle.
Συγγραφείς:
Pratsinis, H.
Kletsas, D.
Melliou, E.
Chinou, I.
Περιοδικό:
Journal of Medicinal Food
Λέξεις-κλειδιά:
cytostatic agent; diterpene; flavonoid; manool; propolis, adenocarcinoma; apitherapy; article; cell cycle G2 phase; cell proliferation; chemistry; colon tumor; drug effect; Greece; human; isolation and purification; tumor cell line, Adenocarcinoma; Apitherapy; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cytostatic Agents; Diterpenes; Flavonoids; G2 Phase; Greece; Humans; Propolis
DOI:
10.1089/jmf.2009.0071
