Dose-response study of effect of oleuropein, an olive oil polyphenol, in an ovariectomy/inflammation experimental model of bone loss in the rat

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:2989230 27 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Dose-response study of effect of oleuropein, an olive oil polyphenol, in an ovariectomy/inflammation experimental model of bone loss in the rat
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background & aims: This study was carried out to assess the dose-dependent bone-sparing effect of oleuropein, an olive oil phenolic compound with anti-inflammatory and anti-oxidative properties, on bone loss induced by talc granulomatosis in oestrogen-deficient rat. Methods: Among 98 rats, 20 were sham-operated (SH) while the others (78) were ovariectomised (OVX). The SH and 26 OVX rats (controls) were given a standard diet for 100 days. The 52 remaining OVX rats were allocated to 4 groups that received oleuropein at 2.5, 5, 10 or 15 mg/kg body weight per day for 100 days. Three weeks before necropsy, an inflammation was induced by subcutaneous injections of talc in half of the SH and OVX rats and in all oleuropein-treated animals. Results: Castration was associated with a decreased bone mineral density (BMD). In OVX rats, inflammation, characterised by an increase of the spleen weight and plasma fibrinogen levels, exacerbated this bone loss, as shown by values of BMD of the total femur metaphyseal and diaphyseal subregions. The 4 doses of oleuropein reduced bone loss and improved inflammatory biomarkers excepted for 5 mg/kg BW. Conclusions: Every dose of oleuropein elicited protective effects on bone mass in this model of ovariectomy associated with inflammation, probably by modulating inflammatory parameters. © 2006 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism.
Έτος δημοσίευσης:
2006
Συγγραφείς:
Puel, C.
Mathey, J.
Agalias, A.
Kati-coulibaly, S.
Mardon, J.
Obled, C.
Davicco, M.-J.
Lebecque, P.
Horcajada, M.-N.
Skaltsounis, A.L.
Coxam, V.
Περιοδικό:
Clinical Nutrition Open Science
Τόμος:
25
Αριθμός / τεύχος:
5
Σελίδες:
859-868
Λέξεις-κλειδιά:
biological marker; casein; fibrinogen; oleuropein; olive oil; polyphenol; talc, animal experiment; animal model; antiinflammatory activity; antioxidant activity; article; autopsy; bone density; castration; controlled study; diaphysis; dietary intake; disease exacerbation; dose response; drug effect; estrogen deficiency; female; fibrinogen blood level; granulomatosis; inflammation; metaphysis; nonhuman; osteolysis; osteopenia; ovariectomy; rat; spleen weight, Animals; Anti-Infective Agents; Biological Markers; Bone Density; Bone Density Conservation Agents; Dose-Response Relationship, Drug; Female; Fibrinogen; Inflammation; Organ Size; Osteoporosis; Ovariectomy; Plant Oils; Pyrans; Random Allocation; Rats; Rats, Wistar; Spleen
Επίσημο URL (Εκδότης):
DOI:
10.1016/j.clnu.2006.03.009
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