Τίτλος:
Effect of traditional Greek Mediterranean meals on platelet aggregation in normal subjects and in patients with type 2 diabetes mellitus
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Patients with type 2 diabetes mellitus have increased risk of cardiovascular disease. Epidemiological studies have shown a correlation between diet and incidence of coronary heart disease. The aim of the study is to determine the effect of a traditional Greek Mediterranean diet on platelet aggregation induced by ADP, arachidonic acid (AA), and especially platelet-activating factor (PAF) on patients with type 2 diabetes mellitus as well as on healthy volunteers. The patients were randomized into two subgroups, A and B. The lipid extracts from traditional Greek Mediterranean-type meals were tested in vitro for their ability to reduce PAF- or thrombin-induced platelet aggregation. The meals with the most potent anti-aggregating activity were chosen for the diet of both subgroup A and healthy subjects and consumed for a period of 28 days, whereas subgroup B kept to their regular diet that was followed before entering the study. Platelet-rich plasma was isolated before and after the diet, and the ability of platelets to aggregate under the aggregating factors was tested. One-month consumption of diet resulted in a significant reduction in PAF- and ADP-induced aggregation of platelets in both groups of healthy volunteers (PAF and ADP, P < .05) and subgroup A (PAF, P < .001; ADP, P < .05), whereas the AA-induced aggregation was not affected. No effect was observed in subgroup B, which followed the standard diet. Thus the consumption of a traditional Greek Mediterranean diet even for a short period can reduce platelet activity in patients suffering from type 2 diabetes mellitus and in healthy subjects. © Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition.
Συγγραφείς:
Antonopoulou, S.
Fragopoulou, E.
Karantonis, H.C.
Mitsou, E.
Sitara, M.
Rementzis, J.
Mourelatos, A.
Ginis, A.
Phenekos, C.
Περιοδικό:
Journal of Medicinal Food
Λέξεις-κλειδιά:
adenosine diphosphate; arachidonic acid; thrombin; thrombocyte activating factor; adenosine diphosphate; arachidonic acid; thrombin; thrombocyte activating factor, animal cell; article; atherosclerosis; cardiovascular risk; clinical article; clinical trial; controlled clinical trial; controlled study; female; Greece; human; ischemic heart disease; male; Mediterranean diet; non insulin dependent diabetes mellitus; nonhuman; priority journal; randomized controlled trial; thrombocyte aggregation; thrombocyte function; thrombocyte rich plasma; adult; aged; blood; diet therapy; drug effect; middle aged; physiology, Subgroup A; Subgroup B, Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Diabetes Mellitus, Type 2; Diet, Mediterranean; Female; Greece; Humans; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Thrombin
DOI:
10.1089/jmf.2006.9.356
