Περίληψη:
In vulnerable populations, such as infants and children, saliva makes the perfect diagnostic medium because of its noninvasive collection, easy handling and storage of samples. Its unique biomarker profiles help tremendously in the diagnosis of many diseases and conditions. In fact, saliva genomics, proteomics, transcriptomics, metabolomics and microbiome-based discoveries have led to complementary and powerful diagnostic information. In children and neonates, saliva is the preferred medium not only for diagnosis of caries and aggressive periodontitis but also for a number of systemic conditions, metabolic diseases, cognitive functions, stress assessment and evaluation of immunological and inflammatory responses to vaccination. In this review, we provide an overview of current and future applications of saliva diagnostics to various diseases and conditions and highlight studies in paediatrics across the “omic” spectrum. Emerging frontiers in salivary diagnostics research that may significantly advance the field are also highlighted. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved
Συγγραφείς:
Pappa, E.
Kousvelari, E.
Vastardis, H.
Λέξεις-κλειδιά:
proteome; saliva protein; biological marker; transcriptome, age; chemical composition; dental caries; human; hypothalamus hypophysis adrenal system; metabolic disorder; microbiome; mouth disease; newborn; nonhuman; omics; pediatrics; periodontal disease; priority journal; proteomics; Review; saliva; saliva analysis; salivation; systemic disease; chemistry; child; genomics; metabolomics; microflora; saliva, Biomarkers; Child; Genomics; Humans; Infant, Newborn; Metabolomics; Microbiota; Pediatrics; Proteomics; Saliva; Transcriptome
