Τίτλος:
The autoimmunity–oral microbiome connection
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
To date, there is a major effort in deciphering the role of complex microbial communities, especially the oral and gut microbiomes, in the pathogenesis of various diseases. Increasing evidence indicates a key role for the oral microbiome in autoimmune diseases. In this review article, we discuss links of the oral microbiota to a group of autoimmune diseases, that is, Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), Crohn's disease (CD), and rheumatoid arthritis (RA). We particularly focus on factors that affect the balance between the immune system and the composition of microbiota leading to dysbiosis, loss of tolerance and subsequent autoimmune disease progression and maintenance. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Συγγραφείς:
Nikitakis, N.G.
Papaioannou, W.
Sakkas, L.I.
Kousvelari, E.
Περιοδικό:
Journal of Oral Diseases
Εκδότης:
Wiley-Blackwell Publishing Ltd
Λέξεις-κλειδιά:
citrulline, arthritis; autoimmune disease; autoimmunity; Crohn disease; human; immunopathogenesis; mouth flora; nonhuman; priority journal; Review; rheumatoid arthritis; Sjoegren syndrome; species composition; systemic lupus erythematosus; virus infection; autoimmunity; Crohn disease; dysbiosis; immunology; intestine flora; microbiology; mouth; rheumatoid arthritis; Sjoegren syndrome; systemic lupus erythematosus, Arthritis, Rheumatoid; Autoimmunity; Crohn Disease; Dysbiosis; Gastrointestinal Microbiome; Humans; Lupus Erythematosus, Systemic; Mouth; Sjogren's Syndrome
