Τίτλος:
Nifedipine-induced histological changes in the parotid glands of hypertensive rats
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Nifedipine is a widely used anti-anginal and anti-hypertensiveagent. It is associated with significant gingival changes attributedmore to collagen hyperplasia than to enhancement of proteinsynthesis. We investigated the influence of nifedipine on morphologicalchanges in the parotid glands of rats in a model of hypertension.Twenty-eight male Wistar rats (8-10 weeks; 200 ± 15 g) were dividedinto four groups (A-D). Hypertension was induced by surgical meansin groups C and D. Animals in groups B and D were treated with nifedipine(0.85 mg/kg) via a gastroesophageal catheter the day after surgery(experimental day-1) for 2 weeks. A significant difference was observedbetween the control group and nifedipine group and betweenthe control group and hypertension group with regard to the weightof the parotid gland and its surface area. Histological findings demonstratedchanges in the parotid glands of hypertensive animals withmild vessel dilatation and infiltration of inflammatory cells. These histologicalfindings seemed to be due more to changes in venous functionthan to alterations in gland architecture.
Συγγραφείς:
Seferos, N.
Daskala, I.
Kotsiou, A.
Tsamouri, M.
Tesseromatis, C.
Περιοδικό:
Brazilian Oral Research
Εκδότης:
Sociedade Brasileira de Hematologia e Hemoterapia
Λέξεις-κλειδιά:
antihypertensive agent; nifedipine; vasodilator agent, animal; article; body weight; chemically induced disorder; disease model; drug effect; hypertension; male; organ size; parotid gland; parotitis; pathology; rat; reference value; Wistar rat, Animals; Antihypertensive Agents; Body Weight; Disease Models, Animal; Hypertension; Male; Nifedipine; Organ Size; Parotid Gland; Parotitis; Rats; Rats, Wistar; Reference Values; Vasodilator Agents
DOI:
10.1590/1807-3107BOR-2014.vol28.0012
