Τίτλος:
Granulomatous Foreign-Body Reaction Involving Oral and Perioral Tissues After Injection of Biomaterials: A Series of 7 Cases and Review of the Literature
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: Injectable implants used for soft-tissue augmentation may lead to a granulomatous foreign-body reaction. The aim of this report is to present 7 new cases of foreign-body granulomas involving the oral and perioral tissues, after injection of biomaterials to achieve soft-tissue augmentation. In addition, the clinical and epidemiological profile of this condition is summarized, based on a review of the English-language literature of all previously described cases. Patients and Methods: We report on 7 new cases of granulomatous foreign-body reaction involving the oral and perioral tissues after the injection of biomaterials. A comprehensive literature review is also presented. Results: The literature search revealed 49 cases of this condition affecting the oral and perioral tissues. Our 7 patients were female, with a mean age of 52.8 years (range, 34 to 70 years). The lower lip was affected in 4 cases, 1 case was located in the upper lip, 1 case in the buccal mucosa, while 1 case involved 2 different sites (upper lip and buccal mucosa). Histopathologic examination revealed numerous cells with clear, often multiple, cytoplasmic vacuoles, bearing a resemblance to lipoblasts. Immunohistochemistry revealed diffuse positivity for the histiocytic marker CD68. Conclusions: The diagnosis of granulomatous foreign-body reactions may be challenging because of their microscopic resemblance to liposarcoma, and because of the occasional reluctance of patients to report the previously performed esthetic procedure. A clinical history, histopathologic examination, and immunohistochemical analysis (as needed) are essential in achieving an accurate diagnosis. © 2009 American Association of Oral and Maxillofacial Surgeons.
Συγγραφείς:
Jham, B.C.
Nikitakis, N.G.
Scheper, M.A.
Papadimitriou, J.C.
Levy, B.A.
Rivera, H.
Περιοδικό:
Asian Journal of Oral and Maxillofacial Surgery
Λέξεις-κλειδιά:
biomaterial; CD68 antigen, adult; aged; article; cheek mucosa; clinical article; controlled study; cytoplasm; female; foreign body granuloma; histiocyte; histopathology; human; immunohistochemistry; lower lip; medical literature; mouth; soft tissue; upper lip, Adult; Aged; Biocompatible Materials; Biopolymers; Body Modification, Non-Therapeutic; Collagen; Cosmetic Techniques; Diagnosis, Differential; Female; Granuloma, Foreign-Body; Humans; Injections; Lip; Lip Neoplasms; Lipoma; Middle Aged; Mouth Mucosa; Tissue Expansion
DOI:
10.1016/j.joms.2008.01.052
