Τίτλος:
Peroxisome proliferator-activated receptor-γ and -δ Polymorphisms in women with polycystic ovary syndrome
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The aim of the study was to examine the frequency and relationship of peroxisome proliferator-activated receptor (PPAR)-γ and PPAR-δ gene polymorphisms to polycystic ovary syndrome (PCOS) characteristics. We conducted a case-control study protocol, which included 183 PCOS women and 148 healthy volunteers. Genetic, clinical, hormonal, and metabolic characteristics of PCOS patients and controls were estimated and compared. Genotype and allele frequencies did not differ significantly. The Pro12Ala polymorphism in exon 2 of the PPAR-γ gene was found in low frequency. Regarding the polymorphism in exon 6, the T-allele carrier PCOS women had significantly lower total testosterone levels. Regarding the +294TC polymorphism in the exon 4 of the PPAR-δ gene, the C-allele carrier PCOS women had significantly higher fasting glucose levels. In conclusion, the PPAR-γ gene polymorphisms do not appear to affect the risk for PCOS, except for the reduced testosterone levels. The +294TC polymorphism in the exon 4 of the PPAR-δ gene seems to cause an increase in fasting glucose levels. © 2010 New York Academy of Sciences.
Συγγραφείς:
Christopoulos, P.
Mastorakos, G.
Gazouli, M.
Deligeoroglou, E.
Katsikis, I.
Diamanti-Kandarakis, E.
Panidis, D.
Creatsas, G.
Περιοδικό:
Annals of the New York Academy of Sciences
Εκδότης:
Blackwell Publishing Inc.
Λέξεις-κλειδιά:
glucose; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor gamma; peroxisome proliferator activated receptor theta; testosterone; unclassified drug; glucose blood level; peroxisome proliferator activated receptor delta; peroxisome proliferator activated receptor gamma; testosterone, adult; allele; case control study; conference paper; controlled study; diet restriction; disease carrier; DNA polymorphism; exon; female; gene frequency; genetics; genotype; glucose blood level; human; major clinical study; ovary polycystic disease; risk; testosterone blood level; volunteer; analysis; blood; clinical trial; genetic polymorphism; genetic predisposition; genetics; multicenter study; ovary polycystic disease; physiology; young adult, Adult; Blood Glucose; Case-Control Studies; Fasting; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Polycystic Ovary Syndrome; Polymorphism, Genetic; PPAR delta; PPAR gamma; Testosterone; Young Adult
DOI:
10.1111/j.1749-6632.2010.05647.x
