Τίτλος:
Poor responders in IVF: Cancellation of a first cycle is not predictive of a subsequent failure
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Management of women with a poor response to controlled ovarian hyperstimulation during IVF remains a frustrating challenge. The present study included 96 cycles from an equal number of women with a poor ovarian response and successful oocyte retrieval. Poor response was defined by the presence of at least one of the following characteristics: three or fewer oocytes on retrieval, serum estradiol level less than 500 pg/mL on the day of hCG administration, and serum FSH levels less than 20 IU/L. The same patients had a previous cycle cancelled because of a poor ovarian response whereas in the second cycle they preferred to continue the treatment despite the poor prognosis. We obtained 241 oocytes in the 96 IVF cycles. The fertilization rate was 60.2%. Three oocytes per cycle were retrieved in 56 cycles (58.3%), two oocytes per cycle in 33 cycles (34.4%), and one oocyte per cycle in 7 cycles (7.3%). In 19 cycles (19.8%) no fertilization was achieved. An embryo transfer was finally performed in 74 out of 96 cycles. Pregnancy rate was 12.5% per cycle and 16.2% per transfer. Among the 12 pregnancies achieved, 7 were in the 3-oocyte cycles and 5 in the 2-oocyte cycles. No pregnancies were achieved in the 1-oocyte cycles. Our data demonstrate that continuation of therapy in poor responders undergoing IVF can be an option despite the low pregnancy rates. The prognosis of these patients is not affected by a poor response in the first cycle and for some of them the outcome can be favorable. © 2006 New York Academy of Sciences.
Συγγραφείς:
Baka, S.
Makrakis, E.
Tzanakaki, D.
Konidaris, S.
Hassiakos, D.
Moustakarias, T.
Creatsas, G.
Περιοδικό:
Annals of the New York Academy of Sciences
Εκδότης:
Blackwell Publishing Inc.
Λέξεις-κλειδιά:
chorionic gonadotropin; estradiol; follitropin; gonadorelin agonist; human menopausal gonadotropin; recombinant follitropin; follitropin; gonadorelin, adult; conference paper; controlled study; embryo transfer; estradiol blood level; female; female infertility; fertilization in vitro; follitropin blood level; human; intracytoplasmic sperm injection; intrauterine insemination; major clinical study; oocyte; ovary function; ovary hyperstimulation; pregnancy rate; treatment failure; treatment outcome; article; clinical trial; drug effect; drug potentiation; fertilization in vitro; oocyte; ovulation induction; pregnancy, Adult; Embryo Transfer; Female; Fertilization in Vitro; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Oocytes; Ovulation Induction; Pregnancy; Pregnancy Rate; Treatment Failure
DOI:
10.1196/annals.1365.040
