Τίτλος:
Steroid receptors in the uterus: Implications in endometriosis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Receptor proteins for estrogens, progesterone, androgens, and glucocorticoids have been detected in the various cell types of the uterus. Reference is made to the genes encoding these receptors, to the structure of the receptor proteins, and their functional domains. The mode of action of steroid hormones by gene activation, through their cognate receptors, and by nongenomic effects is briefly presented. The role of the steroid receptors in uterine physiology and the significance of the use of steroid receptor knock-out animals in delineating the in vivo action of the hormones is discussed. Recent results on the possible correlation of steroid receptor gene polymorphisms and of quantitative and qualitative changes in the receptor proteins to the etiopathology of endometriosis are reviewed.
Συγγραφείς:
Moutsatsou, P.
Sekeris, C.E.
Περιοδικό:
Annals of the New York Academy of Sciences
Εκδότης:
THE NEW YORK ACADEMY OF SCIENCES
Λέξεις-κλειδιά:
androgen; androgen receptor; estrogen; estrogen receptor; glucocorticoid; glucocorticoid receptor; progesterone; progesterone receptor; receptor subtype; receptor subunit; steroid hormone; steroid receptor; androgen receptor; estrogen receptor; glucocorticoid receptor; progesterone receptor, amino acid composition; chromosomal localization; conference paper; disease predisposition; DNA polymorphism; drug effect; drug mechanism; endometriosis; gene activation; gene activity; genetic transcription; hormonal regulation; hormone action; human; pathophysiology; protein domain; protein function; protein localization; protein structure; sequence homology; signal transduction; tissue distribution; binding site; female; hospitalization; metabolism; pathology; prognosis; review; risk assessment; sensitivity and specificity; transport at the cellular level; uterus, Animalia, Binding Sites; Biological Transport; Endometriosis; Female; Humans; Prognosis; Receptors, Androgen; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Progesterone; Receptors, Steroid; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Uterus
DOI:
10.1196/annals.1290.024
