Τίτλος:
Early effect of sodium valproate and carbamazepine monotherapy on homocysteine metabolism in children with epilepsy
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Plasma total homocysteine (p-tHcy), serum folate (s-F), serum vitamin B-12 (s-B12) and plasma pyridoxal-5′-phosphate (p-PLP) were measured in epileptic children before and after a 20-week period of sodium valproate (group A, n = 32) and carbamazepine (group B, n = 20) monotherapy. P-tHcy significantly increased in both groups, s-F and s-B12 significantly increased in group A, while s-F and p-PLP significantly decreased in group B. Our study showed an early effect of antiepileptic drug treatment on homocysteine metabolism. © 2006 Elsevier B.V. All rights reserved.
Συγγραφείς:
Attilakos, A.
Papakonstantinou, E.
Schulpis, K.
Voudris, K.
Katsarou, E.
Mastroyianni, S.
Garoufi, A.
Περιοδικό:
Epilepsy Research
Λέξεις-κλειδιά:
carbamazepine; cyanocobalamin; folic acid; homocysteine; pyridoxal 5 phosphate; valproic acid, abnormally high substrate concentration in blood; adolescent; amino acid blood level; amino acid metabolism; article; child; controlled study; epilepsy; female; folic acid blood level; follow up; human; major clinical study; male; monotherapy; phosphate blood level; priority journal; treatment outcome; vitamin blood level, Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Prospective Studies; Pyridoxal Phosphate; Valproic Acid; Vitamin B 12
DOI:
10.1016/j.eplepsyres.2006.06.015
