Τίτλος:
Early and persistent increase in serum lipoprotein (a) concentrations in epileptic children treated with carbamazepine and sodium valproate monotherapy
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: The aim of this study was to investigate by a prospective, self-controlled method, whether treatment with carbamazepine (CBZ) and sodium valproate (VPA) monotherapy may alter serum lipoprotein (a) [Lp(a)] concentrations in epileptic children. Methods: Serum Lp(a) concentrations have been determined in 18 epileptic children before and at 6, 12 and 24 months of treatment with CBZ monotherapy and in 30 epileptic children before and at 6, 12 and 24 months of treatment with VPA monotherapy. Serum total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoproteins A-I and B concentrations and serum concentrations of biochemical markers of liver and renal function were also measured in the study participants. Results: Serum Lp(a) concentrations were significantly increased at 6, 12 and 24 months of CBZ and VPA monotherapy. There were no significant correlations between serum Lp(a) and serum lipids, lipoproteins, apolipoproteins, concentrations of biochemical markers of liver and renal function or antiepileptic-drugs concentrations. Conclusions: Children who receive CBZ or VPA monotherapy may have significant and persistent increase in serum lipoprotein (a) concentrations, occuring early in the course of therapy. It may be useful to measure serum Lp(a) concentrations routinely in epileptic children taking these antiepileptic drugs, especially in those that are already at higher atherosclerotic risk. © 2006 Elsevier B.V. All rights reserved.
Συγγραφείς:
Voudris, K.A.
Attilakos, A.
Katsarou, E.
Drakatos, A.
Dimou, S.
Mastroyianni, S.
Skardoutsou, A.
Prassouli, A.
Garoufi, A.
Περιοδικό:
Epilepsy Research
Λέξεις-κλειδιά:
anticonvulsive agent; apolipoprotein A1; apolipoprotein B; carbamazepine; cholesterol; high density lipoprotein cholesterol; lipid; lipoprotein A; low density lipoprotein cholesterol; triacylglycerol; valproic acid, abnormally high substrate concentration in blood; article; atherosclerosis; child; cholesterol blood level; clinical article; correlation analysis; disease course; disease marker; epilepsy; female; human; kidney function; lipid blood level; lipoprotein blood level; liver function; male; measurement; mental concentration; monotherapy; priority journal; risk assessment; risk factor; statistical significance; triacylglycerol blood level, Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Lipids; Lipoprotein(a); Male; Prospective Studies; Time Factors; Valproic Acid
DOI:
10.1016/j.eplepsyres.2006.05.002
