Περίληψη:
Background: Age-related macular degeneration (AMD) is a progressive, multifactorial, degenerative disease and the leading cause of severe visual loss in the elderly population. The exact pathogenesis of AMD remains elusive, being the combination of genetic, environmental, metabolic, and functional processes. A better understanding of the disease's pathophysiology can lead to new treatment targets. The human microbiome seems to be a potential therapeutic pathway for AMD, as it has been recently proven to play a role in its pathogenesis. Summary: This review sheds light on the association between the microbiome and AMD. Key Messages: The current evidence based on the existing literature shows that there are differences in taxonomical and functional profiles in the human microbiome between patients with AMD and controls, suggesting that the microbiome is implicated in AMD onset and progression, being a link between AMD and nutrition/diet. Additionally, specific bacterial classes have been proposed as potential biomarkers for AMD diagnosis. Further randomized clinical studies with a large sample are needed to elucidate the role of the microbiome in AMD and to draw more solid conclusions. © 2021 S. Karger AG, Basel. Copyright: All rights reserved.
Συγγραφείς:
Zisimopoulos, A.
Klavdianou, O.
Theodossiadis, P.
Chatziralli, I.
Λέξεις-κλειδιά:
biological marker; complement factor H; HLA DR antigen; neomycin; nucleotide binding oligomerization domain like receptor; pathogen associated molecular pattern; prothrombin; RNA 16S; toll like receptor, Actinomyces; Actinomycetaceae; age related macular degeneration; Bacteroides; blindness; body weight; Clostridiales; cross reaction; degenerative disease; dysbiosis; Firmicutes; Gemella; glycemic index; human; hypertension; immune response; inflammation; intestine flora; Lachnospiraceae; Leptotrichia; lipid diet; microbial community; microbial diversity; microbiome; mouse; nonhuman; nutrition; obesity; photoreceptor; Prevotella; Proteobacteria; randomized controlled trial (topic); retinal pigment epithelium; Review; risk factor; Ruminococcaceae; Ruminococcus; smoking; Staphylococcus; Streptococcus; T lymphocyte activation; TLR signaling; Veillonella; visual impairment; aged; macular degeneration; microflora, Aged; Biomarkers; Humans; Macular Degeneration; Microbiota
