Τίτλος:
Blood biomarkers in frontotemporal dementia: Review and meta-analysis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Biomarkers in cerebrospinal fluid (CSF) are useful in the differential diagnosis between frontotemporal dementia (FTD) and Alzheimer’s dementia (AD), but require lumbar puncture, which is a moderately invasive procedure that can cause anxiety to patients. Gradually, the measurement of blood biomarkers has been attracting great interest. Testing blood instead of CSF, in order to measure biomarkers, offers numerous advantages because it negates the need for lumbar puncture, it is widely available, and can be repeated, allowing the prediction of disease course. In this study, a systematic review of the existing literature was conducted, as well as meta-analysis with greater emphasis on the most studied biomarkers, p-tau and progranulin. The goal was to give prominence to evidence regarding the use of plasma biomarkers in clinical practice. © 2021 by the authors.
Συγγραφείς:
Ntymenou, S.
Tsantzali, I.
Kalamatianos, T.
Voumvourakis, K.I.
Kapaki, E.
Tsivgoulis, G.
Stranjalis, G.
Paraskevas, G.P.
Περιοδικό:
Brain Sciences
Λέξεις-κλειδιά:
3,4 dihydroxyphenylacetic acid; amyloid beta protein; biological marker; gamma interferon; glial fibrillary acidic protein; homocysteine; immunoglobulin G; interleukin 15; interleukin 6; progranulin; tau protein; tumor necrosis factor, Alzheimer disease; anxiety; Article; astrocyte; astrocytosis; autism; body mass; brain atrophy; cerebrospinal fluid analysis; clinical practice; cognitive defect; differential diagnosis; diffusion tensor imaging; disease severity; enzyme linked immunosorbent assay; frontotemporal dementia; genetic heterogeneity; genotype; gluten free diet; human; lumbar puncture; meta analysis; microglia; neuropsychological test; nuclear magnetic resonance imaging; prevalence; randomized controlled trial (topic); sensitivity and specificity; systematic review; upregulation
DOI:
10.3390/brainsci11020244
