Τίτλος:
Serum Uric Acid in LRRK2 Related Parkinson's Disease: Longitudinal Data from the PPMI Study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Previous studies have highlighted serum uric acid as a putative idiopathic Parkinson's disease (iPD) biomarker. Only one study, so far, showed higher levels of serum uric acid in leucine-rich repeat kinase 2 (LRRK+2) carriers compared to those who developed PD, however a longitudinal comparison between LRRK2+PD and healthy controls (HC) has not been performed. Objective: The aim of this study was to determine whether there are longitudinal differences in serum uric acid between iPD, LRRK2+PD and HC and their association with motor and non-motor features. Methods: Longitudinal data of uric acid of 282 de novo iPD, 144 LRRK2+PD patients, and 195 age-matched HC were obtained from the Parkinson's Progression Markers Initiative (PPMI) database. We also used longitudinal Montreal Cognitive Assessment (MoCA), Movement Disorder Society-Unified Parkinson's Disease Rating Scale part III (MDS-UPDRS-III), Geriatric Depression Scale (GDS) scores, and DaTSCAN striatal binding ratios (SBRs). Results: Longitudinal uric acid measurements were significantly lower in LRRK2+PD patients compared to HC up to 5 years follow-up. There was no significant impact or correlation of adjusted or unadjusted uric acid levels with MoCA, MDS-UPDRS III, or GDS scores, the presence of RBD or DAT-SCAN SBRs. Conclusion: LRRK2+PD group had significantly lower uric acid concentrations compared to HC after adjusting for age, sex and baseline BMI up to 5 years follow-up. There were no significant associations between uric acid levels and indices of disease severity. These findings identify serum uric acid as a marker linked to LRRK2+PD. © 2021 - IOS Press. All rights reserved.
Συγγραφείς:
Bougea, A.
Koros, C.
Papagiannakis, N.
Simitsi, A.-M.
Prentakis, A.
Papadimitriou, D.
Pachi, I.
Antonelou, R.
Angelopoulou, E.
Beratis, I.
Bozi, M.
Papageorgiou, S.G.
Trapali, X.G.
Stamelou, M.
Stefanis, L.
Περιοδικό:
Journal of Parkinson's Disease
Λέξεις-κλειδιά:
leucine rich repeat kinase 2; uric acid; biological marker; leucine rich repeat kinase 2; LRRK2 protein, human; uric acid, adult; aging; Article; body mass; cohort analysis; comparative study; controlled study; disease severity; female; follow up; Geriatric Depression Scale; human; longitudinal study; LRRK2 gene; major clinical study; male; middle aged; Montreal cognitive assessment; Parkinson disease; pathogenesis; priority journal; sex ratio; Unified Parkinson Disease Rating Scale; uric acid blood level; aged; chemistry; genetics; metabolism; mutation; Parkinson disease, Aged; Biomarkers; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mutation; Parkinson Disease; Uric Acid
