Περίληψη:
Total CSF α-synuclein (t-α-syn), phosphorylated α-syn (pS129-α-syn) and α-syn oligomers (o-α-syn) have been studied as candidate biomarkers for synucleinopathies, with suboptimal specificity and sensitivity in the differentiation from healthy controls. Studies of α-syn species in patients with other underlying pathologies are lacking. The aim of this study was to investigate possible alterations in CSF α-syn species in a cohort of patients with diverse underlying pathologies. A total of 135 patients were included, comprising Parkinson’s disease (PD; n = 13), multiple system atrophy (MSA; n = 9), progressive supranuclear palsy (PSP; n = 13), corticobasal degeneration (CBD; n = 9), Alzheimer’s disease (AD; n = 51), frontotemporal degeneration (FTD; n = 26) and vascular dementia patients (VD; n = 14). PD patients exhibited higher pS129-α-syn/α-syn ratios compared to FTD (p = 0.045), after exclusion of samples with CSF blood contamination. When comparing movement disorders (i.e., MSA vs. PD vs. PSP vs. CBD), MSA patients had lower α-syn levels compared to CBD (p = 0.024). Patients with a synucleinopathy (PD and MSA) exhibited lower t-α-syn levels (p = 0.002; cut-off value: ≤865 pg/mL; sensitivity: 95%, specificity: 69%) and higher pS129-/t-α-syn ratios (p = 0.020; cut-off value: ≥0.122; sensitivity: 71%, specificity: 77%) compared to patients with tauopathies (PSP and CBD). There are no significant α-syn species alterations in non-synucleinopathies. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Constantinides, V.C.
Majbour, N.K.
Paraskevas, G.P.
Abdi, I.
Safieh-Garabedian, B.
Stefanis, L.
El-Agnaf, O.M.
Kapaki, E.
Λέξεις-κλειδιά:
alpha synuclein; biological marker; tau protein, adult; Alzheimer disease; Article; cerebrospinal fluid; cognitive defect; dementia; diagnostic test accuracy study; disease duration; female; gene expression; human; major clinical study; male; middle aged; motor dysfunction; multiinfarct dementia; nerve degeneration; neurofibrillary tangle; neuropsychological test; Parkinson disease; parkinsonism; progressive supranuclear palsy; protein expression; receiver operating characteristic; sensitivity and specificity; synucleinopathy; tauopathy
