Περίληψη:
Purpose: The aim of this study was to evaluate the characteristics of corneal endothelial cells and central corneal thickness (CCT) in patients with diabetes mellitus (DM), comparing them with those of healthy subjects (controls) and to determine potential factors affecting the corneal parameters in patients with DM. Methods: Participants in this study were 72 patients with DM and 88 healthy controls. Diabetic patients were further classified into groups depending on the severity of diabetic retinopathy (no retinopathy, mild, moderate, severe non-proliferative diabetic retinopathy, and proliferative diabetic retinopathy). All participants underwent non-contact specular microscopy to evaluate corneal endothelium parameters and CCT, while factors affecting endothelial cell density and CCT in patients with DM were also analyzed. Results: Patients with DM presented significantly decreased endothelial cell density compared to controls (2,297.9 ± 311.3 and 2,518.3 ± 243.7 cells/mm2, respectively; p < 0.001), while the two groups did not differ significantly in any other measured corneal parameter. In the diabetic group, the multivariate analysis showed a significant association between decreased endothelial cell density and increased HbA1c (p < 0.001), longer DM duration (p = 0.003), and more severe diabetic retinopathy status (p = 0.008). Conclusion: DM seems to affect the corneal endothelium, since endothelial cell density was decreased in the diabetic group, while duration of disease, HbA1c levels, and severity of retinopathy were significantly associated with changes in endothelial cell density and should be taken into account. © 2020 S. Karger AG. All rights reserved.
Συγγραφείς:
Papadakou, P.
Chatziralli, I.
Papathanassiou, M.
Lambadiari, V.
Siganos, C.S.
Theodossiadis, P.
Kozobolis, V.
Λέξεις-κλειδιά:
hemoglobin A1c; glycosylated hemoglobin, aged; Article; case control study; cell density; central corneal thickness; controlled study; cornea endothelium; diabetes mellitus; diabetic retinopathy; disease association; disease duration; disease severity; female; human; major clinical study; male; nonproliferative diabetic retinopathy; priority journal; proliferative diabetic retinopathy; specular microscopy; blood; cell count; cornea endothelium; diabetic retinopathy; disease exacerbation; follow up; metabolism; pathology; retrospective study; time factor, Aged; Cell Count; Diabetic Retinopathy; Disease Progression; Endothelium, Corneal; Female; Follow-Up Studies; Glycated Hemoglobin A; Humans; Male; Retrospective Studies; Time Factors
