Τίτλος:
Paraneoplastic cerebellar degeneration in a patient with breast cancer associated with carbonic anhydrase–related protein VIII autoantibodies
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Paraneoplastic cerebellar degeneration is a neurological syndrome resulting from immune-mediated dysfunction of Purkinje cells and commonly is associated with a tumor. In most cases, well-characterized onconeural antibodies are detected, such as anti-Yo and anti-Ri antibodies. Carbonic anhydrase-related protein VIII (CARP VIII) antibodies associated with paraneoplastic cerebellar degeneration have been previously described in only two cases. Herein, we present a 75-year-old female who developed progressive cerebellar ataxia. Anti-CARP VIII autoantibodies were found at high titres and screening for underlying malignancies revealed a breast cancer. Intravenous immunoglobulin was administered with poor results. Our report further confirms the role of CARP VIII antibodies in cerebellar degeneration. © 2020 Elsevier B.V.
Συγγραφείς:
Prevezianou, A.
Tzartos, J.S.
Dagklis, I.E.
Bentenidi, E.
Angelopoulos, P.
Bostantjopoulou, S.
Περιοδικό:
Journal of Neuroimmunology
Λέξεις-κλειδιά:
autoantibody; carbonate dehydratase; carbonic anhydrase related protein VIII; immunoglobulin; oligoclonal band; paclitaxel; unclassified drug; autoantibody; CA8 protein, human; protein binding; tumor marker, aged; antibody titer; Article; Babinski reflex; bradyphrenia; breast cancer; cancer adjuvant therapy; cancer surgery; case report; cerebellum disease; cerebrospinal fluid analysis; clinical article; cytoplasm; diplopia; dizziness; drug withdrawal; dysarthria; dyskinesia; dysmetria; female; follow up; gait disorder; human; immobility; leukoencephalopathy; leukopenia; multiple cycle treatment; neurologic examination; nuclear magnetic resonance imaging; paraneoplastic neuropathy; priority journal; protein cerebrospinal fluid level; Purkinje cell; tremor; animal; breast tumor; cerebellum; complication; Haplorhini; HEK293 cell line; metabolism; paraneoplastic neuropathy; pathology; physiology, Aged; Animals; Autoantibodies; Biomarkers, Tumor; Breast Neoplasms; Cerebellum; Female; Haplorhini; HEK293 Cells; Humans; Paraneoplastic Cerebellar Degeneration; Protein Binding
DOI:
10.1016/j.jneuroim.2020.577242
