Περίληψη:
Background: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive. Objective: To assess the associations between alcohol consumption and PD risk. Methods: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence. Results: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5–29.9 g/day) were at ~50% higher risk compared with light consumption (0.1–4.9 g/day), but no linear exposure–response trend was observed. Analyses by beverage type also revealed no associations with PD. Conclusion: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Συγγραφείς:
Peters, S.
Gallo, V.
Vineis, P.
Middleton, L.T.
Forsgren, L.
Sacerdote, C.
Sieri, S.
Kyrozis, A.
Chirlaque, M.-D.
Zamora-Ros, R.
Hansson, O.
Petersson, J.
Katzke, V.
Kühn, T.
Mokoroa, O.
Masala, G.
Ardanaz, E.
Panico, S.
Bergmann, M.M.
Key, T.J.
Weiderpass, E.
Ferrari, P.
Vermeulen, R.
Λέξεις-κλειδιά:
adult; aged; alcohol consumption; Article; cohort analysis; demography; Europe; female; human; lifespan; major clinical study; male; Parkinson disease; priority journal; prospective study; risk; adverse event; coffee; drinking behavior; Parkinson disease; risk factor, Alcohol Drinking; Coffee; Cohort Studies; Humans; Male; Parkinson Disease; Prospective Studies; Risk Factors
