Τίτλος:
Colchicine for stroke prevention in patients with coronary artery disease: a systematic review and meta-analysis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background and purpose: Although clinical trials suggest that colchicine may reduce the risk of vascular events in patients with a history of coronary artery disease, its effect on the prevention of cerebrovascular events still remains unclear. Methods: A systematic review and meta-analysis was performed of all available randomized controlled trials (RCTs) reporting on incident strokes during the follow-up of patients with a history of cardiovascular disease randomized to colchicine treatment or control (placebo or usual care). Results: Four RCTs were identified, including a total of 5553 patients (mean age 61 years, 81% males), with a follow-up ranging from 1 to 36 months. Colchicine treatment was associated with a significantly lower risk of incident stroke during follow-up compared to control (risk ratio 0.31, 95% confidence interval 0.13–0.71), without heterogeneity across included studies (I2 = 0%). Based on the pooled incident stroke rate of control groups (0.9%) in the included RCTs, it was estimated that administration of low-dose colchicine to 161 patients with coronary artery disease would prevent one stroke during a follow-up of 23 months. Conclusion: Colchicine treatment decreases stroke risk in patients with a history of coronary artery disease. The effect of colchicine in secondary stroke prevention is currently being evaluated in an ongoing RCT. © 2020 European Academy of Neurology
Συγγραφείς:
Katsanos, A.H.
Palaiodimou, L.
Price, C.
Giannopoulos, S.
Lemmens, R.
Kosmidou, M.
Georgakis, M.K.
Weimar, C.
Kelly, P.J.
Tsivgoulis, G.
Περιοδικό:
European Journal of Paediatric Neurology
Εκδότης:
Wiley-Blackwell Publishing Ltd
Λέξεις-κλειδιά:
colchicine, Article; cerebrovascular accident; coronary artery disease; follow up; human; incidence; low drug dose; meta analysis; priority journal; randomized controlled trial (topic); risk reduction; systematic review; therapy effect
