Τίτλος:
Role of GTPases in the Regulation of Mitochondrial Dynamics in Alzheimer’s Disease and CNS-Related Disorders
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Data obtained from several studies have shown that mitochondria are involved and play a central role in the progression of several distinct pathological conditions. Morphological alterations and disruptions on the functionality of mitochondria may be related to metabolic and energy deficiency in neurons in a neurodegenerative disorder. Several recent studies demonstrate the linkage between neurodegeneration and mitochondrial dynamics in the spectrum of a promising era called precision mitochondrial medicine. In this review paper, an analysis of the correlation between mitochondria, Alzheimer’s disease, and other central nervous system (CNS)-related disorders like the Parkinson’s disease and the autism spectrum disorder is under discussion. The role of GTPases like the mfn1, mfn2, opa1, and dlp1 in mitochondrial fission and fusion is also under investigation, influencing mitochondrial population and leading to oxidative stress and neuronal damage. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς:
Alexiou, A.
Soursou, G.
Chatzichronis, S.
Gasparatos, E.
Kamal, M.A.
Yarla, N.S.
Perveen, A.
Barreto, G.E.
Ashraf, G.M.
Περιοδικό:
Molecular Neurobiology
Εκδότης:
Humana Press Inc.
Λέξεις-κλειδιά:
guanosine triphosphatase; guanosine triphosphatase, Alzheimer disease; cell death; cell population; central nervous system disease; clinical feature; complex formation; disease association; disorders of mitochondrial functions; human; mitochondrial dynamics; mitophagy; nerve conduction; nonhuman; oxidative stress; pathogenesis; Review; risk factor; Alzheimer disease; animal; biological model; central nervous system disease; enzymology; metabolism; mitochondrion, Alzheimer Disease; Animals; Central Nervous System Diseases; GTP Phosphohydrolases; Humans; Mitochondria; Mitochondrial Dynamics; Models, Biological
DOI:
10.1007/s12035-018-1397-x
