Ερευνητικό υλικό ΕΚΠΑ

Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia

Αγγλικά

Introduction: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia. Methods: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models. Results: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini–Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E ε4 (1.8 [1.3-2.5]) increased the risk of dementia. Discussion: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts. © 2018 The Authors

2019

Slot, R.E.R.
Sikkes, S.A.M.
Berkhof, J.
Brodaty, H.
Buckley, R.
Cavedo, E.
Dardiotis, E.
Guillo-Benarous, F.
Hampel, H.
Kochan, N.A.
Lista, S.
Luck, T.
Maruff, P.
Molinuevo, J.L.
Kornhuber, J.
Reisberg, B.
Riedel-Heller, S.G.
Risacher, S.L.
Roehr, S.
Sachdev, P.S.
Scarmeas, N.
Scheltens, P.
Shulman, M.B.
Saykin, A.J.
Verfaillie, S.C.J.
Visser, P.J.
Vos, S.J.B.
Wagner, M.
Wolfsgruber, S.
Jessen, F.
Boada, M.
de Deyn, P.P.
Jones, R.
Frisoni, G.
Spiru, L.
Nobili, F.
Freund-Levi, Y.
Soininen, H.
Verhey, F.
Wallin, Å.K.
Touchon, J.
Rikkert, M.O.
Rigaud, A.-S.
Bullock, R.
Tsolaki, M.
Vellas, B.
Wilcock, G.
Froelich, L.
Bakardjian, H.
Benali, H.
Bertin, H.
Bonheur, J.
Boukadida, L.
Boukerrou, N.
Chiesa, P.
Colliot, O.
Dubois, B.
Dubois, M.
Epelbaum, S.
Gagliardi, G.
Genthon, R.
Habert, M.-O.
Houot, M.
Kas, A.
Lamari, F.
Levy, M.
Metzinger, C.
Mochel, F.
Nyasse, F.
Poisson, C.
Potier, M.-C.
Revillon, M.
Santos, A.
Andrade, K.S.
Sole, M.
Surtee, M.
Thiebaud de Schotten, M.
Vergallo, A.
Younsi, N.
van der Flier, W.M.
Alzheimer's Disease Neuroimaging Initiative
DESCRIPA working group
INSIGHT-preAD study group
SCD-I working group

American Journal of Alzheimer's Disease and other Dementias

ELSEVIER SCIENCE INC 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA

15

3

465-476

apolipoprotein E4, adult; aged; Alzheimer disease; Article; cognition assessment; cognitive defect; cohort analysis; controlled study; dementia; disease exacerbation; female; frontotemporal dementia; human; incidence; major clinical study; male; memory; Mini Mental State Examination; priority journal; risk assessment; risk factor; subjective cognitive decline; very elderly; clinical trial; cognitive defect; dementia; middle aged; multicenter study; psychology; self concept; self evaluation, Aged; Aged, 80 and over; Cognitive Dysfunction; Cohort Studies; Dementia; Diagnostic Self Evaluation; Disease Progression; Female; Humans; Incidence; Male; Middle Aged; Risk Factors; Self Concept

https://doi.org/10.1016/j.jalz.2018.10.003

10.1016/j.jalz.2018.10.003

https://pergamos.lib.uoa.gr/uoa/dl/object/2997872