Τίτλος:
Stroke recurrence and mortality in northeastern Greece: the Evros Stroke Registry
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Up to date there is no population-based study from Greece providing long-term data on incidence of both all-cause mortality and stroke recurrence for patients with first ever stroke (FES). Adult patients with FES were registered during a 24-month period (2010–2012) and followed-up for 12 months. We calculated cumulative incidences of stroke mortality and recurrence. Univariable and multivariable Cox proportional hazards regression analyses were used to identify independent determinants of 1-year mortality and 1-year stroke recurrence. We prospectively documented 703 first ever stroke cases (mean age 75 ± 12 years; 52.8% males; ischemic stroke 80.8%, intracerebral hemorrhage 11.8%, subarachnoid hemorrhage 4.4%, undefined 3.0%) with a total follow-up time of 119,805 person-years. The cumulative incidence rates of mortality of all FES patients at 28 days, 3 months and 1 year were 21.3% (95% CI 18.5–24.5%), 26% (95% CI 22.9–29.4%) and 34.7% (95% CI 31.3–38.3%), respectively. The risk of 1-year mortality was independently (p < 0.05) associated with advancing age, history of hypertension, increased stroke severity on admission, and hemorrhagic FES type. Cumulative 1-year stroke mortality differed according to both index FES type (ischemic vs. hemorrhage; p < 0.001), but also across different ischemic stroke subtypes (p = 0.025). The cumulative incidence rates of recurrent stroke at 28 days, 3 months and 1 year were 2.0% (95% CI 1.2–3.6%), 4.2% (2.8–6.2%) and 6.7% (5.1–8.8%), respectively. Comparable to other population-based surveys, our study reports 1-year mortality and stroke recurrence rates in patients with FES. These findings highlight the need for effective secondary prevention strategies in a border region of southeastern Europe, which exhibits very high FES incidence rates. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
Συγγραφείς:
Tsivgoulis, G.
Katsanos, A.H.
Patousi, A.
Pikilidou, M.
Birbilis, T.
Mantatzis, M.
Yavropoulou, M.
Zompola, C.
Triantafyllou, S.
Papanas, N.
Skendros, P.
Terzoudi, A.
Georgiadis, G.S.
Zebekakis, P.
Maltezos, E.
Piperidou, C.
Heliopoulos, I.
Vadikolias, K.
Περιοδικό:
Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Εκδότης:
Dr. Dietrich Steinkopff Verlag GmbH and Co. KG
Λέξεις-κλειδιά:
adult; age; aged; Article; brain hemorrhage; brain ischemia; cerebrovascular accident; comparative study; controlled study; disease registry; female; follow up; Greece; health survey; human; hypertension; incidence; major clinical study; male; medical history; mortality; mortality rate; mortality risk; priority journal; prospective study; recurrence risk; recurrent disease; risk assessment; stroke patient; stroke survivor; subarachnoid hemorrhage; cerebrovascular accident; Greece; middle aged; recurrent disease; very elderly, Adult; Aged; Aged, 80 and over; Brain Ischemia; Cerebral Hemorrhage; Female; Follow-Up Studies; Greece; Humans; Incidence; Male; Middle Aged; Prospective Studies; Recurrence; Stroke; Subarachnoid Hemorrhage
DOI:
10.1007/s00415-018-9005-6
