Τίτλος:
OCT-Angiography for monitoring and managing neovascular age-related macular degeneration
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: To evaluate the combined use of optical coherence tomography and angiography (OCT-A) for imaging choroidal neovascularization (CNV) secondary to neovascular age-related macular degeneration (nAMD). Materials and Methods: This prospective observational study was conducted from May 2015 to April 2017. Included in the study were 54 patients (n = 63 eyes), all of whom had CNV secondary to nAMD and all of whom had been examined by OCT-A. Angioscans (3x3 and 6 × 6) and conventional B-scan OCT scans were obtained for all patients at baseline and at various times during the 24-month follow-up period. For diagnostic confirmation, conventional imaging methods fluorescein angiography (FA) and indocyanine green angiography (ICGA) were performed at baseline. A total of 13 patients (n = 15 eyes) underwent serial imaging during 34 follow-up visits. The main outcomes included (i) determination of OCT-A sensitivity for the detection of CNV (classic and occult) and (ii) the correlation between B-scan OCT and OCT-A vis-à-vis consecutive follow-up changes. Results: At baseline, the detection rate (i.e., overall sensitivity) of OCT-A for detecting CNV was 64.4% (75.7 and 48.0% for classic and occult CNV, respectively), independent of prior treatment status. In terms of quality, 6 × 6 angioscans were superior to 3 × 3. Moreover, specific CNV morphologic patterns by B-scan OCT did not correlate with lesion composition. Correspondence between OCT-A and B-scan OCT was observed in only 53% of the cases. Conclusions: OCT-A may prove to be a valuable adjunctive diagnostic tool for the interpretation of CNV, as it not only reduces the need for invasive angiographic procedures but also facilitates the follow-up process. © 2017 Taylor & Francis Group, LLC.
Συγγραφείς:
Malamos, P.
Tsolkas, G.
Kanakis, M.
Mylonas, G.
Karatzenis, D.
Oikonomopoulos, N.
Lakoumentas, J.
Georgalas, I.
Περιοδικό:
Current Eye Research
Εκδότης:
Taylor and Francis Ltd.
Λέξεις-κλειδιά:
adult; Article; B scan; fluorescence angiography; follow up; human; indocyanine green angiography; intermethod comparison; major clinical study; observational study; optical coherence tomography; optical coherence tomography angiography; priority journal; subretinal neovascularization; wet macular degeneration; aged; antagonists and inhibitors; female; fluorescence angiography; male; middle aged; multimodal imaging; optical coherence tomography; physiology; prospective study; sensitivity and specificity; subretinal neovascularization; visual acuity; wet macular degeneration, angiogenesis inhibitor; coloring agent; indocyanine green; vasculotropin A; VEGFA protein, human, Aged; Angiogenesis Inhibitors; Choroidal Neovascularization; Coloring Agents; Female; Fluorescein Angiography; Humans; Indocyanine Green; Male; Middle Aged; Multimodal Imaging; Prospective Studies; Sensitivity and Specificity; Tomography, Optical Coherence; Vascular Endothelial Growth Factor A; Visual Acuity; Wet Macular Degeneration
DOI:
10.1080/02713683.2017.1356336
