Περίληψη:
PURPOSE. The purpose of this study was to evaluate the role of inflammatory/lipid markers and potential risk factors for diabetic retinopathy (DR) development in newly diagnosed patients with type 2 diabetes mellitus (T2DM). METHODS. Participants in this study were 1062 patients with newly diagnosed T2DM. Demographic and clinical data of patients were collected. Assessment of DR status was performed using digital two-field photography. In addition, HbA1c (%), lipid profile, and urinary albumin were measured at recruitment. The following inflammatory markers were also measured: serum C-reactive protein, white blood cells, platelet, adiponectin, IL-4, IL-6, IL-10, vascular endothelial growth factor, tumor necrosis factor-a (TNF-a), IL-1b, IL-1 receptor antagonist (IL-1RA), and monocyte chemotactic protein-1. Univariate and multivariate analyses of the association of various potential risk factors and DR were conducted. RESULTS. Univariate analysis showed that male sex, any cardiovascular event, and HbA1c were positively associated with DR, while IL-1RA, IL-1b, IL-6, and TNF-a were significantly negatively associated with presence of DR in the cohort. Risk factors that remained significantly associated with DR presence at the multivariate analysis were male sex, any cardiovascular event, HbA1c, and IL-1RA. CONCLUSIONS. Our study demonstrated that HbA1c levels, male sex, and previous cardiovascular events were risk factors for presence of DR in people with newly diagnosed T2DM, while IL-1RA seemed to have a protective role. The prevalence of DR in our population was 20.2%, reflecting current practice. Our findings may contribute to future risk-based modelling of screening for DR. © 2017 The Authors.
Συγγραφείς:
Chatziralli, I.
Sergentanis, T.N.
Crosby-Nwaobi, R.
Winkley, K.
Eleftheriadis, H.
Ismail, K.
Amiel, S.A.
Sivaprasad, S.
Λέξεις-κλειδιά:
adiponectin; albumin; C reactive protein; hemoglobin A1c; high density lipoprotein cholesterol; interleukin 1 receptor blocking agent; interleukin 10; interleukin 1beta; interleukin 4; interleukin 6; low density lipoprotein cholesterol; monocyte chemotactic protein 1; triacylglycerol; tumor necrosis factor; vasculotropin; biological marker; glycosylated hemoglobin; interleukin derivative; lipid; tumor necrosis factor, adult; affinity chromatography; aged; Article; cerebrovascular accident; coronary artery bypass graft; diabetic retinopathy; diastolic blood pressure; enzyme linked immunosorbent assay; erectile dysfunction; female; gender; heart infarction; human; laser coagulation; leg revascularization; leukocyte count; major clinical study; male; microalbuminuria; non insulin dependent diabetes mellitus; priority journal; risk factor; systolic blood pressure; thrombocyte count; albuminuria; blood; complication; diabetic retinopathy; mass screening; middle aged; non insulin dependent diabetes mellitus; procedures; statistical model; urine, Aged; Albuminuria; Biomarkers; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Hemoglobin A, Glycosylated; Humans; Interleukins; Lipids; Logistic Models; Male; Mass Screening; Middle Aged; Risk Factors; Tumor Necrosis Factor-alpha
