Τίτλος:
Manual MRI morphometry in Parkinsonian syndromes
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Several morphometric magnetic resonance imaging parameters may serve for differential diagnosis of parkinsonism. The objective of this study was to identify which performs best in clinical routine. Methods: We acquired multicentric magnetization-prepared rapid gradient echo sequences in patients with Parkinson's disease (n=204), progressive supranuclear palsy (n=106), multiple system atrophy-cerebellar, (n = 21); multiple system atrophy-parkinsonian (n = 60), and healthy controls (n = 73), performed manual planimetric measurements, and calculated receiver operator characteristics with leave-one-out cross-validation to propose cutoff values. Results: The midsagittal midbrain area was reduced in PSP versus all other groups (P < 0.001). The midsagittal pons area was reduced in MSA-cerebellar, MSA-parkinsonian, and PSP versus PD patients and healthy controls (P < 0.001). The midbrain/pons area ratio was lower in PSP (P < 0.001) and higher in MSA-cerebellar and MSA-parkinsonian versus PD and PSP (P < 0.001). Conclusions: The midsagittal midbrain area most reliably identified PSP, the midsagittal pons area MSA-cerebellar. The midbrain/pons area ratio differentiated MSA-cerebellar and PSP better than the magnetic resonance-Parkinson index. © 2017 International Parkinson and Movement Disorder Society. © 2017 International Parkinson and Movement Disorder Society
Συγγραφείς:
Möller, L.
Kassubek, J.
Südmeyer, M.
Hilker, R.
Hattingen, E.
Egger, K.
Amtage, F.
Pinkhardt, E.H.
Respondek, G.
Stamelou, M.
Möller, F.
Schnitzler, A.
Oertel, W.H.
Knake, S.
Huppertz, H.-J.
Höglinger, G.U.
Περιοδικό:
Movement Disorders
Εκδότης:
John Wiley and Sons Inc
Λέξεις-κλειδιά:
adult; aged; Article; brain atrophy; cerebellum; cerebellum atrophy; clinical practice; controlled study; diagnostic test accuracy study; female; human; interrater reliability; magnetism; major clinical study; male; measurement; mesencephalon; middle aged; middle cerebellar peduncle; morphometry; multicenter study; neuroimaging; nuclear magnetic resonance imaging; Parkinson disease; parkinsonism; pons; predictive value; priority journal; progressive supranuclear palsy; receiver operating characteristic; Shy Drager syndrome; superior cerebellar peduncle; very elderly; brain; case control study; diagnostic imaging; nuclear magnetic resonance imaging; Parkinson disease; parkinsonism; pathophysiology; progressive supranuclear palsy; reproducibility; Shy Drager syndrome, Adult; Aged; Aged, 80 and over; Brain; Case-Control Studies; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multiple System Atrophy; Parkinson Disease; Parkinsonian Disorders; Reproducibility of Results; ROC Curve; Supranuclear Palsy, Progressive
