Τίτλος:
Decreased Axon Flare Reaction to Electrical Stimulation in Patients with Chronic Demyelinating Inflammatory Polyneuropathy
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: In chronic inflammatory demyelinating polyradiculopathy (CIDP), the impairment of unmyelinated nerve fibers appears unexpected. The measurement of the electrically induced axon flare reflex is a clinical test to assess the peripheral C-nociceptor function. In this study, we compared the flare area in patients suffering from CIDP with healthy subjects. Methods: We examined 18 patients fulfilling the criteria for CIDP (11 men, mean age 51.8 years, SD 15.1) and 18 age-matched adult healthy volunteers (control group) (11 men, mean age 51.9 years, SD 15.8). The flare responses were elicited by transcutaneous electrical stimulation and recorded by laser Doppler imaging. Results: There was a significant reduction of electrically induced maximum flare area in the foot dorsum of patients with CIDP (t-value 2.08, P = 0.04) which proved to be length-dependent measured by a numerical index comparing the results with the forearm and thigh. The repeatedmeasures ANOVA revealed statistically significant smaller flare areas in all body regions for the CIDP group (P < 0.001). Conclusions: The axon flare reaction to electrical stimulation was decreased in patients with chronic demyelinating inflammatory polyneuropathy. The evaluation of the axon flare response can be proposed as a noninvasive objective functional test to detect an impaired C-fiber function in CIDP patients with the advantages of simplicity of the procedure, time economy, and objectivity. © 2016 by the American Clinical Neurophysiology Society.
Συγγραφείς:
Kokotis, P.
Schmelz, M.
Papagianni, A.E.
Zambelis, T.
Karandreas, N.
Περιοδικό:
Journal of Clinical Neurophysiology
Εκδότης:
Lippincott Williams and Wilkins
Λέξεις-κλειδιά:
action potential; adult; aged; Article; axon; axon flare reaction; body regions; chronic inflammatory demyelinating polyneuropathy; clinical article; controlled study; electrostimulation; female; human; male; middle aged; nerve fiber degeneration; nerve function; pain threshold; sensory nerve; sensory nerve conduction; sural nerve; transcutaneous electrical nerve stimulation; upper limb; young adult; axon; electrostimulation; innervation; pathophysiology; physiology; polyradiculoneuropathy; reflex; skin, Adult; Aged; Axons; Electric Stimulation; Female; Humans; Male; Middle Aged; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Reflex; Skin
DOI:
10.1097/WNP.0000000000000294
