Τίτλος:
Weight gain in children on oxcarbazepine monotherapy
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Studies of the effect of oxcarbazepine (OXC) on body growth of children with epilepsy are rare and their results are controversial. To the contrary, many studies have shown significant weight gain following valproate (VPA) treatment. Purpose: To prospectively evaluate the effect of OXC monotherapy on growth patterns of children with epilepsy and compare it with the effect of VPA monotherapy. Method: Fifty-nine otherwise healthy children, aged 3.7-15.9 years, with primary generalized, partial or partial with secondary generalization seizure disorder, were included in the study. Twenty six children were placed on OXC and thirty three on VPA monotherapy. Body weight (BW), height and body mass index (BMI) as well as their standard deviation scores (SDS), were evaluated prior to as well as 8 months post initiation of OXC or VPA therapy. Results: Eight months post OXC-treatment, BW, SDS-BW, BMI and SDS-BMI increased significantly. The increase was similar to that observed in the VPA group. An additional 15.4% of children in the OXC group and 21.2% in the VPA group became overweight or obese. The effect of both OXC and VPA therapy on linear growth did not reach statistical significance. Conclusion: Similarly to VPA, OXC monotherapy resulted in a significant weight gain in children with epilepsy. Careful monitoring for excess weight gain along with counseling on adapting a healthy lifestyle should be offered to children on OXC therapy. © 2016 Elsevier B.V.
Συγγραφείς:
Garoufi, A.
Vartzelis, G.
Tsentidis, C.
Attilakos, A.
Koemtzidou, E.
Kossiva, L.
Katsarou, E.
Soldatou, A.
Περιοδικό:
Epilepsy Research
Λέξεις-κλειδιά:
oxcarbazepine; valproic acid; anticonvulsive agent; carbamazepine; oxcarbazepine; valproic acid, adolescent; Article; body height; body mass; child; child growth; controlled study; drug effect; epilepsy; female; focal epilepsy; human; major clinical study; male; monotherapy; obesity; preschool child; priority journal; prospective study; school child; side effect; tonic clonic seizure; weight gain; analogs and derivatives; drug effects; epilepsy; weight gain, Adolescent; Anticonvulsants; Body Mass Index; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Prospective Studies; Valproic Acid; Weight Gain
DOI:
10.1016/j.eplepsyres.2016.03.004
