Ερευνητικό υλικό ΕΚΠΑ

A genome-wide association study of anorexia nervosa

Αγγλικά

Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting; 1445 AN binge-purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P = 3.01 × 10-7) in SOX2OT and rs17030795 (P = 5.84 × 10-6) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P = 5.76 × 10-6) between CUL3 and FAM124B and rs1886797 (P = 8.05 × 10-6) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P = 4 × 10-6), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field. © 2014 Macmillan Publishers Limited All rights reserved.

2014

Boraska, V.
Franklin, C.S.
Floyd, J.A.B.
Thornton, L.M.
Huckins, L.M.
Southam, L.
Rayner, N.W.
Tachmazidou, I.
Klump, K.L.
Treasure, J.
Lewis, C.M.
Schmidt, U.
Tozzi, F.
Kiezebrink, K.
Hebebrand, J.
Gorwood, P.
Adan, R.A.H.
Kas, M.J.H.
Favaro, A.
Santonastaso, P.
Fernández-Aranda, F.
Gratacos, M.
Rybakowski, F.
Dmitrzak-Weglarz, M.
Kaprio, J.
Keski-Rahkonen, A.
Raevuori, A.
Van Furth, E.F.
Slof-Op 't Landt, M.C.T.
Hudson, J.I.
Reichborn-Kjennerud, T.
Knudsen, G.P.S.
Monteleone, P.
Kaplan, A.S.
Karwautz, A.
Hakonarson, H.
Berrettini, W.H.
Guo, Y.
Li, D.
Schork, N.J.
Komaki, G.
Ando, T.
Inoko, H.
Esko, T.
Fischer, K.
Männik, K.
Metspalu, A.
Baker, J.H.
Cone, R.D.
Dackor, J.
DeSocio, J.E.
Hilliard, C.E.
O'Toole, J.K.
Pantel, J.
Szatkiewicz, J.P.
Taico, C.
Zerwas, S.
Trace, S.E.
Davis, O.S.P.
Helder, S.
Bühren, K.
Burghardt, R.
De Zwaan, M.
Egberts, K.
Ehrlich, S.
Herpertz-Dahlmann, B.
Herzog, W.
Imgart, H.
Scherag, A.
Scherag, S.
Zipfel, S.
Boni, C.
Ramoz, N.
Versini, A.
Brandys, M.K.
Danner, U.N.
De Kovel, C.
Hendriks, J.
Koeleman, B.P.C.
Ophoff, R.A.
Strengman, E.
Van Elburg, A.A.
Bruson, A.
Clementi, M.
Degortes, D.
Forzan, M.
Tenconi, E.
Docampo, E.
Escaramís, G.
Jiménez-Murcia, S.
Lissowska, J.
Rajewski, A.
Szeszenia-Dabrowska, N.
Slopien, A.
Hauser, J.
Karhunen, L.
Meulenbelt, I.
Slagboom, P.E.
Tortorella, A.
Maj, M.
Dedoussis, G.
Dikeos, D.
Gonidakis, F.
Tziouvas, K.
Tsitsika, A.
Papezova, H.
Slachtova, L.
Martaskova, D.
Kennedy, J.L.
Levitan, R.D.
Yilmaz, Z.
Huemer, J.
Koubek, D.
Merl, E.
Wagner, G.
Lichtenstein, P.
Breen, G.
Cohen-Woods, S.
Farmer, A.
McGuffin, P.
Cichon, S.
Giegling, I.
Herms, S.
Rujescu, D.
Schreiber, S.
Wichmann, H.-E.
Dina, C.
Sladek, R.
Gambaro, G.
Soranzo, N.
Julia, A.
Marsal, S.
Rabionet, R.
Gaborieau, V.
Dick, D.M.
Palotie, A.
Ripatti, S.
Widén, E.
Andreassen, O.A.
Espeseth, T.
Lundervold, A.
Reinvang, I.
Steen, V.M.
Le Hellard, S.
Mattingsdal, M.
Ntalla, I.
Bencko, V.
Foretova, L.
Janout, V.
Navratilova, M.
Gallinger, S.
Pinto, D.
Scherer, S.W.
Aschauer, H.
Carlberg, L.
Schosser, A.
Alfredsson, L.
Ding, B.
Klareskog, L.
Padyukov, L.
Courtet, P.
Guillaume, S.
Jaussent, I.
Finan, C.
Kalsi, G.
Roberts, M.
Logan, D.W.
Peltonen, L.
Ritchie, G.R.S.
Barrett, J.C.
Anderson, C.A.
McGinnis, R.
Zeggini, E.
Sambrook, J.
Stephens, J.
Ouwehand, W.H.
McArdle, W.L.
Ring, S.M.
Strachan, D.P.
Alexander, G.
Bulik, C.M.
Collier, D.A.
Conlon, P.J.
Dominiczak, A.
Duncanson, A.
Hill, A.
Langford, C.
Lord, G.
Maxwell, A.P.
Morgan, L.
Sandford, R.N.
Sheerin, N.
Vannberg, F.O.
Blackburn, H.
Chen, W.-M.
Edkins, S.
Gillman, M.
Gray, E.
Hunt, S.E.
Onengut-Gumuscu, S.
Potter, S.
Rich, S.S.
Simpkin, D.
Whittaker, P.
Estivill, X.
Hinney, A.
Sullivan, P.F.
The Wellcome Trust Case Control Consortium 3

Journal of Molecular Psychiatry

Nature Publishing Group

19

10

1085-1094

cullin; cullin 3; FAM124B protein; PPP3CA protein; protein; SPATA13 protein; transcription factor Sox2; unclassified drug; calcineurin; carrier protein; CUL3 protein, human; cullin; FAM124B protein, human; guanine nucleotide exchange factor; nuclear protein; PPP3CA protein, human; SPATA13 protein, human, ancestry group; anorexia nervosa; Article; attention deficit disorder; bipolar disorder; body mass; comparative study; computer model; controlled study; female; genome-wide association study; genotype; human; major clinical study; major depression; nerve cell network; obesity; priority journal; schizophrenia; single nucleotide polymorphism; synapse; anorexia nervosa; Asian continental ancestry group; case control study; Caucasian; genetics; genome-wide association study; Japan; male; meta analysis (topic), Anorexia Nervosa; Asian Continental Ancestry Group; Calcineurin; Carrier Proteins; Case-Control Studies; Cullin Proteins; European Continental Ancestry Group; Female; Genome-Wide Association Study; Guanine Nucleotide Exchange Factors; Humans; Japan; Male; Meta-Analysis as Topic; Nuclear Proteins; Polymorphism, Single Nucleotide

https://doi.org/10.1038/mp.2013.187

10.1038/mp.2013.187

https://pergamos.lib.uoa.gr/uoa/dl/object/2998851