Τίτλος:
HLA-DRB1*15:01 and Epstein-Barr virus in a multiple sclerosis patient with psoriasis, nasopharyngeal and breast cancers. Lessons for possible hidden links for autoimmunity and cancer
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background Multiple sclerosis (MS) patients have a low general cancer risk and cases of neoplastic comorbidity are attributed by many researchers in chance, or therapeutical side-effects. Human leucocyte antigen (HLA) class II allele DRB1*15:01 is considered the main genetic factor independently associated with increased susceptibility for MS in Caucasians. Epstein-Barr virus (EBV) has also been proven to be a core triggering factor in MS initiation and progress, mainly in HLA-DRB1*15:01 positive MS patients. Case report We present an exceptional case of a Greek-origin woman, carrying a distinct immunogenetic profile (HLA-A*26:01-Cw*06:02-DRB1*15:01), which gradually developed psoriasis, nasopharyngeal carcinoma (NPC), MS, breast cancer, uterine leiomyoma and other neoplasms. Discussion EBV plays a fundamental role in the pathogenesis of both autoimmunity (i.e. MS) and cancer (i.e. NPC). Our patient's immunogenetic profile included HLA alleles which are associated with psoriasis (Cw*06:02), NPC (A*26:01), MS (DRB1*15:01) and increased risk of MS, in patients carrying EBV (DRB1*15:01). We made a targeted review of the literature finding data supporting an EBV-HLA interaction mechanism behind our patient's unique combination of disorders, suggesting that beyond the standard role of each factor, their combination could act as the hidden link, in initiation or/and comorbidity of autoimmunity and cancer. © 2014 Elsevier B.V.
Συγγραφείς:
Anagnostouli, M.
Anagnostoulis, G.
Katsavos, S.
Panagiotou, M.
Kararizou, E.
Davaki, P.
Περιοδικό:
Journal of the Neurological Sciences
Λέξεις-κλειδιά:
beta interferon; HLA DRB1 antigen; methotrexate; methylprednisolone; oligoclonal band; HLA DRB1 antigen; HLA-DRB1*15:01 antigen, autoimmunity; blurred vision; breast cancer; case report; cognitive defect; depression; disease course; Epstein Barr virus infection; female; follow up; hospital admission; human; immunogenetics; immunopathogenesis; limb dysesthesia; lumbar puncture; multiple sclerosis; nasopharynx cancer; neurologic examination; nuclear magnetic resonance imaging; optic neuritis; priority journal; psoriasis; review; serology; unsteady gait; uterus myoma; autoimmunity; blood; Breast Neoplasms; Epstein Barr virus; immunology; metabolism; middle aged; multiple sclerosis; Nasopharyngeal Neoplasms; psoriasis, Autoimmunity; Breast Neoplasms; Female; Follow-Up Studies; Herpesvirus 4, Human; HLA-DRB1 Chains; Humans; Middle Aged; Multiple Sclerosis; Nasopharyngeal Neoplasms; Psoriasis
DOI:
10.1016/j.jns.2014.02.003
