Τίτλος:
Reactivity to AQP4 epitopes in relapsing-remitting multiple sclerosis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Autoantibodies against the water channel AQP4, expressed predominately in central nervous system astrocytes, are markers and pathogenic factors in Devic's disease. In this study we examined whether Multiple Sclerosis (MS) patients recognize antigenic epitopes on AQP4 that may define distinct disease subsets. We screened sera from 45 patients with relapsing-remitting MS (RRMS) and 13 patients with primary progressive MS (PMS). 23 Neuromyelitis Optica (NMO) patients previously characterized were used as assay positive/negative controls. Sera from 23 patients with Systemic Lupus Erythematosus, 23 with primary Sjogren syndrome without neurological involvement and from 28 healthy individuals were also used as controls. NMO-positive sera exhibited reactivity against the intracellular epitope AQPaa252-275, confirming previous observations. All RRMS sera tested negative for anti-AQP4 antibodies using a cell-based assay, but surprisingly, 13% of them reacted with the epitope AQPaa252-275. PMS, healthy and disease controls showed no specific reactivity. Whether these antibodies define distinct MS subsets and have a pathogenic potential pointing to convergent pathogenetic mechanism with NMO, or are simply markers of astrocytic damage, remains to be determined. © 2013 Elsevier B.V.
Συγγραφείς:
Alexopoulos, H.
Kampylafka, E.I.
Chatzi, I.
Travasarou, M.
Karageorgiou, K.E.
Dalakas, M.C.
Tzioufas, A.G.
Περιοδικό:
Journal of Neuroimmunology
Λέξεις-κλειδιά:
aquaporin 4; epitope, adult; article; clinical article; controlled study; enzyme linked immunosorbent assay; Expanded Disability Status Scale; female; human; multiple sclerosis; myelooptic neuropathy; optic neuritis; priority journal; Sjoegren syndrome; systemic lupus erythematosus, Adolescent; Adult; Antibody Specificity; Aquaporin 4; Astrocytes; Autoantibodies; Demyelinating Diseases; Epitope Mapping; Epitopes; Female; Humans; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Neuromyelitis Optica; Young Adult
DOI:
10.1016/j.jneuroim.2013.04.017
